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SARS-CoV蛋白质组的生物信息学及其进化关系 被引量：6

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摘要 一种新的冠状病毒SARS-CoV是引起严重急性呼吸综合征(severe acute respiratory syndrome,SARS)的病原体,对由SARS病毒全基因组序列推导出的所有蛋白质逐一进行分子量、等电点、分子消光系数等物理化学性质计算,以及跨膜区和亚细胞定位预测,辅以保守序列家族数据库搜索,预测SARS-CoV功能未知蛋白质的功能,同时,通过SARS-CoV与其他冠状病毒蛋白质同源序列比较和进化距离计算,分析SARS病毒的分类地位以及与其他冠状病毒的进化关系。结果表明,尽管SARS病毒是不同于其他3组冠状病毒的一种全新冠状病毒,但在进化关系上更靠近牛冠状病毒BoCoV和鼠肝炎病毒MHV。为实验测定SARS病毒蛋白质组以及抗SARS疫苗研制提供了参考和帮助。
作者 柳树群 过涛 季星来 孙之荣
机构地区 清华大学生物科学与技术系
出处 《科学通报》 EI CAS CSCD 北大核心 2003年第13期1359-1368,共10页 Chinese Science Bulletin
关键词 SARS-CoV蛋白质组 生物信息学 进化 严重急性呼吸综合征 保守序列家族 冠状病毒
分类号 R346 [医药卫生—基础医学]
  • 相关文献

参考文献27

  • 1[1]Peiris J S M, Lai S T, Poon L L M. Coronavirus as a possible cause of severe acute respiratory syndrome. Lancet, 2003, 361: 1319～1325
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  • 4秦鄂德,祝庆余,于曼,范宝昌,常国辉,司炳银,杨保安,彭文明,姜涛,刘伯华,邓永强,刘洪,张雨,王翠娥,李豫川,甘永华,李晓萸,吕富双,谭刚,曹务春,杨瑞馥,汪建,李蔚,徐祖元,李彦,吴清发,林伟,陈维军,唐琳,邓亚军,韩玉军,李昌峰,雷蒙,李国庆,李文杰,吕宏,石建萍,童宗中,张峰,李松岗,刘斌,刘斯奇,董伟,王俊,黄家树,于军,杨焕明.SARS相关病毒(BJ01株)的全序列及其比较分析[J].科学通报,2003,48(11):1127-1134. 被引量：17
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二级参考文献11

  • 1[1]Poutanen S M, Low D E, Henry B, et al. Identification of severe acute respiratory syndrome in Canada. N Engl J Med, 2003, 348: 1995～2005
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共引文献16

同被引文献42

  • 1秦鄂德,祝庆余,于曼,范宝昌,常国辉,司炳银,杨保安,彭文明,姜涛,刘伯华,邓永强,刘洪,张雨,王翠娥,李豫川,甘永华,李晓萸,吕富双,谭刚,曹务春,杨瑞馥,汪建,李蔚,徐祖元,李彦,吴清发,林伟,陈维军,唐琳,邓亚军,韩玉军,李昌峰,雷蒙,李国庆,李文杰,吕宏,石建萍,童宗中,张峰,李松岗,刘斌,刘斯奇,董伟,王俊,黄家树,于军,杨焕明.SARS相关病毒(BJ01株)的全序列及其比较分析[J].科学通报,2003,48(11):1127-1134. 被引量：17
  • 2[2]Tsang KW,Ho PL,Ooi GC,et al. A cluster of cases of severe acute respiratory syndrome in Hong Kong[J]. N Eng J Med,2003,348:1977.
  • 3[3]Lee N,Hui D,Wu A,et al. A major outbreak of severe acute respiratory syndrome in Hong Kong[J]. N Engl J Med,2003,348:1986.
  • 4[4]Poutanen SM,Low DE,Henry B,et al. Identification of severe acute respiratory syndrome in Canada[J]. N Engl J Med,2003,348:1995.
  • 5[5]Peiris JS,Lai ST,Poon LL,et al. Coronavirus as a possible cause of severe acute respiratory syndrome[J]. Lancet,2003,361:1319.
  • 6[6]Drosten C,Günther S,Preiser W,et al. Identification of a novel coronavirus in patient with severe respiratory syndrome[J]. N Eng J Med,2003,348:1967.
  • 7[7]Ksiazek TG,Erdman D,Goldsmith CS,et al. A novel coronavirus associated with severe acute respiratory syndrome[J]. N Engl J Med,2003,348:1953.
  • 8[8]Rota PA,Oberste MS,Monroe SS,et al. Characterization of a novel coronavirus associated with severe acute respiratory syndrome[J]. Science,2003,300:1394.
  • 9[10]Marra MA,Jones SJ,Astell CR,et al. The genome sequence of the SARS-associated coronavirus[J]. Science,2003,300:1399.
  • 10[11]Jun RY,Lin WC,Ling AE,et al. Comparative full-length genome sequence analysis of 14 SARS coronavirus isolated and common mutation associated with putative origin of infection[J]. Lancet,2003,361:1779.

引证文献6

二级引证文献18

科学通报
2003年 第13期

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