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盆腔子宫内膜异位症患者血清和腹腔液可溶性细胞间粘附分子-1水平的测定 被引量：2

Soluble intracellular adhesion molecule-1 concentrations in the serum and peritoneal fluid from endometriosis patients
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摘要 目的 :探讨盆腔子宫内膜异位症 (EMS)患者血清和腹腔液中可溶性细胞间粘附分子 1(sICAM 1)的表达水平与该病的关系。　方法 :以酶联免疫吸附测定法 (ELISA)定量检测盆腔EM患者血清 35例、腹腔液 30例 ,对照组血清 2 6例、腹腔液 4例的sICAM 1水平。　结果 :①EM组血清sICAM 1水平明显高于对照组 ,差异显著 (P <0 .0 5 )。②两组腹腔液sICAM 1水平无显著差异 (P >0 .0 5 )。　结论 :盆腔EM患者血清sICAM 1水平明显升高 ,提示sICAM Objectives:To investigate the level of soluble intracellular adhesion molecule 1 (sICAM 1) concentrations in the serum and peritoneal fluid from the patients with or without endometriosis.To discuss the relationship within sICAM 1 and pelvic endometriosis. Methods:35 serum and 30 peritoneal fluid of patients with endometriosis (test group) and 26 serum and 4 peritoneal fluid without endometriosis (control group) were studied.Soluble intracellular adhesion molecule 1 levels were detected by an enzyme linked immunoassay(ELISA).The results were analysed by T test. Results: The serum concentration of sICAM 1 was significantly higher in test group than controll group. However,There was no significant difference in between two groups. Conclusions: These results suggest that sICAM 1 could play some role in the persistence of endometriotic lesions.
作者 周秋明 吴元赭 沙金燕 秦卫松
机构地区 第二军医大学附属长海医院妇产科 南京军区南京总医院妇产科 南京军区南京总医院检验科
出处 《医学研究生学报》 CAS 2003年第5期358-360,共3页 Journal of Medical Postgraduates
关键词 子宫内膜异位症 可溶性细胞间粘附分子-1 酶联免疫吸附测定 Endometriosis Solubo intracellular adhesion molecule 1 ELISA
分类号 R711.71 [医药卫生—妇产科学]
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参考文献9

  • 1Dan I,Lebovic MD,Mueller MD et al.Immunobiology of endometriosis[J]. Fertil Steril, 2001,75(1):1-10.
  • 2Daniel Y,Geva E,Amit A et al.Do soluble cell adhesion molecules play a role in endometriosis?[J] Am J Reprod Immunol,2000,43(3):160-166.
  • 3Somigliana E,Vigano P,Gaffuri B et al.Human endometrial stromal cell as a source of soluble intercellular adhesion molecule(ICAM)-1 molecules. Hum Reprod,1996,11(6):1190-1194.
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同被引文献18

  • 1刘木彪,何援利,陈燕英.子宫内膜异位症患者血清血管内皮生长因子与内抑素的测定及其临床意义[J].医学研究生学报,2004,17(7):613-615. 被引量：5
  • 2伍俊萍,张惜阴.子宫内膜异位症患者血清CA_（125）、抗子宫内膜抗体的测定[J].中华妇产科杂志,1996,31(9):562-562. 被引量：27
  • 3Edgardo S, Paola V, Massimo C, et al. Use of serum-soluble intercellular adhesion molecule-1 as a new marker of endometriosis [J]. Fertil Steril,2002,77(5):1 028.
  • 4Opala T, Drews K, Rzymski P,et al. Evaluation of soluble intracellular adhesion molecule-1 (slCAM-1) in benign and malignant ovarian masses[J]. Eur J Gynaecol Oncol, 2003, 24(3-4):255.
  • 5Goluda M, Goluda M, Kuliczkowski K,et al. The concentration of exfoliative adhesion molecules(ICAM-1 and E-Selectin) in serum and peritoneal fluid of women with endometriosis[J]. Ginekol Pol, 1998,69 (12) : 1 175.
  • 6De Placido G, Alviggi C, Di Palma, et al. Serum concentrations of soluble human leukocyte class I antigens and of the soluble intercellular adhesion molecule-I in endometriosis:relationship with stage and non-pigmentedperitoneal lesions[J]. Hum Reprod,1998,13(11) :3 206.
  • 7Nagamasa M,Chiaki I, Hiroyoshi O,et al. Aberrant expression of intercellular adhesion molecule-1 and killer inhibitory receptors induces immune tolerance in women with pelvic endometriosis [J]. Fertil Steril,2002,77 (4) : 679.
  • 8Vigano P,Di Blasio AM,Somigliana E, et al. Suppression of Natural Killer Cell Function and Production of Soluble ICAM-I: Endometrial Stroma Versus Melanoma[J]. AmJ Reprod Immunol, 2001, 46(5):342.
  • 9曹泽毅.中华妇产科学[M].北京：人民卫生出版社,1999.2129.
  • 10Starzinski-Powitz A,Handraw-Metzmacher H,Kotzia S.The putative role of cell adhesion molecules in endometriosis:Can we learn from tumour metastasis?[J] Molecular Medicine Today,1999,5(7):304-309.

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医学研究生学报
2003年 第5期

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