茉莉酮酸甲酯类似物的新方法

Novel Approach to Some Analogues of Methyl Jasmonate

茉莉酮酸甲脂是茉莉花的主香成份。由于化合物的香气与其化学结构密切相关,故自Demole合成了二氢茉莉酮酸甲酯以来,又相继报道了二氢异茉莉酮酸甲脂和二氢新茉莉酮甲酸脂等几个异构体的合成。这些化合物都具有茉莉的韵调、但又有着各自独特的香气。本文报道另一类茉莉酮酸甲醇的类似物2-烃基-3-氧-环戊基-乙酸甲脂(1),2-亚苄基-3-氧-

Michael addition of litho-trimethyl silyl acetate 4 to cyclopentenone yields 5, wh-ich adds to valeraldehyde to give the hydroxy compound 3. and reacts with aromatic aldehy-de to afford the dehydrates 2.5 can also be alkylated with active alkyl, allyl or benzyl hal-ides to give thecorrespounding analogues 1a～1c of methyl jasmonate.