2-氯甲基苯并恶唑的Darzens反应研究

Darzens Reaction of 2-Chloromethylbenzoxazole

Darzens反应研究中的一项重要工作是寻找其它能反应的α-卤代物,现在已知α-卤代酯,α-卤代酮,α-卤代腈和α-卤代矾以及对硝基氯化苄和个9-氯代芴均能与醛、酮反应生成环氧化合物。本文报道的是用2-

2-chloromethylbenzoxazole reacted with aromatic aldehydes and cyclic ketones inN, N-dimethylformamide suspension of potassium hydroxide, giving the expected Darzens typereaction products: 2-aryl-3-(2'-benzoxazolyl) oxiranes. The cis- and trans- isomers were de-termined with ~1H NMR spectroscopy.