3-(2-喹啉基)酚酮的卤代和硝化反应

Halogenation and Nitration of 3-(2-Quinolyl) tropolone

众所周知酚酮环可以进行多种亲电取代反应。我们曾研究过3—乙酰基酚酮、3—乙酰胺基酚酮和3—肉桂酰基酚酮的亲电取代反应。最近报道了喹啉基取代酚酮的合成。

3-(2-Quinolyl) tropolone reacts with bromine to afford 5-bromo-3-(2-quinolyl) tropolone and 5,7-dibromo-3-(2-quinolyl) tropololone dependig upon amounts of the rea- gent. Iodination and nitration of 3-(2-quinolyl) tropolone give 5-iodo-3-(2-quinolyl) tro- tropolone and 5-nitro-3-(2-quinolyl) tropolone, respectively. 3-[2-(2-6′,7′-Methylenedioxy) quinolyl] tropolone reacts with nitric acid to afford 5,7-dinitro-3-[6,′7′-methylenedioxy) quinolyl]tropolone.