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炎性因子遗传多态性与Alzheimer病 被引量：8

Genetic polymorphisms of inflammatory factors and Alzheimer's disease
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摘要 炎性因子在Alzheimer病 (简称AD)中的作用越来越受到研究者的重视 ,成为研究AD发病机制的又一热点。近来的研究表明 ,炎性因子遗传多态性与AD的发病和发展相关 ,为寻找AD相关基因提供了新的线索。本文总结分析了各种炎性因子IL 1、IL 6、TNF α、趋化因子及补体等参与AD发病的机制 。 Inflammatory factors play an important role in the pathogenesis of Alzheimer's disease (AD) and has become a hot spot in the research on AD etiology. Recent studies showed that the genetic polymorphisms of inflammatory factors were associated with AD risk and progression, indicating a new clue for searching new candidate genes of AD. This review elucidates the mechanisms of various factors, i.e. IL-1, IL-6, TNF-α, chemokine and complement in AD pathogenesis. The association of these genetic polymorphisms with AD was also summarized.
作者 李晓青 张俊武
机构地区 中国医学科学院中国协和医科大学基础医学研究所医学分子生物学国家重点实验室
出处 《基础医学与临床》 CSCD 北大核心 2004年第1期7-11,共5页 Basic and Clinical Medicine
基金 CMB项目 ( 99 699)
关键词 炎性因子 遗传多态性 ALZHEIMER病 发病机制 白介素1 白介素6 肿瘤坏死因子 老年痴呆 Alzheimer's disease inflammatory factors polymorphisms
分类号 R749.1 [医药卫生—神经病学与精神病学]
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参考文献34

  • 1[1]Griffin WS,Stanley LC,Ling C,et al.Brain interleukin 1,and S-100 immunoreactivity are elevated in Down syndrome,and Alzheimer disease[J].Proc Natl Acad Sci USA,1989,86(19):7611-7615.
  • 2[2]Nicoll JA,Mrak RE,Graham DI,et al.Association of interleukin-1 gene polymorphisms with Alzheimer's disease[J].Ann Neurol,2000,47(3):365-368.
  • 3[3]Grimaldi LM,Casadei VM,Ferri C,et al.Association of early onset Alzheimer's disease with an Interleukin-1α gene polymorphism[J].Ann Neurol,2000,47(3):361-365.
  • 4[4]Combarros O,Sanchez-Guerra M,Infante J,et al.Gene dose-dependent association of interleukin-1A[-889]allele 2 polymorphism with Alzheimer's disease[J].J Neurol,2002,249(9):1242-1245.
  • 5[5]Du Y,Dodel RC,Eastwood BJ,et al.Association of an interleukin 1 alpha polymorphism with Alzheimer's disease[J].Neurology,2000,55(4):480-483.
  • 6[6]Hedley R,Hallmayer J,Groth DM,et al.Association of interleukin-1 polymorphisms with Alzheimer's disease in Australia[J].Ann Neurol,2002,51(6):795-797.
  • 7[7]Rebeck GW.Confirmation of the genetic association of interleukin-1A with early onset sporadic Alzheimer's disease[J].Neurosci Lett,2000,293(1):75-77.
  • 8[8]Fidani L,Goulas A,Mirtsou V,et al.Interleukin-1A polymorphism is not associated with late onset Alzheimer's disease[J].Neurosci Lett,2002,323(1):81-83.
  • 9[9]Green EK,Harris JM,Lemmon H,et al.Are interleukin-1 gene polymorphisms risk factors or disease modifiers in AD?[J].Neurology,2002,58(10):1566-1568.
  • 10[10]Ki CS,Na DL,Kim DK,et al.Lack of association of the interleukin-1alpha gene polymorphism with Alzheimer's disease in a Korean population[J].Ann Neurol,2001,49(6):817-818.

同被引文献62

  • 1周晓辉,程新春.炎性细胞因子在Alzheimer病发病中的作用[J].临床神经病学杂志,2007,20(5):397-398. 被引量：7
  • 2吴林,李鹏.老年性痴呆辨证论治探讨[J].实用中医内科杂志,2009,23(8):13-14. 被引量：4
  • 3杜冠华.血管内皮细胞损伤机制及保护药物的研究[J].基础医学与临床,2004,24(3):258-263. 被引量：43
  • 4朱海波,王振华,田京伟,傅风华,刘坷,李长龄.羟基红花黄色素A对实验性脑缺血的保护作用[J].药学学报,2005,40(12):1144-1146. 被引量：55
  • 5[1]Selkoe DJ.Normal and abnormal biology of the beta--amyloid precursor protein[J].Annu Rev Neurosci,1994,17:489-517.
  • 6[2]Panchal M,Rholam,Brakch N.Abnormalities of peptide metabolism in Alzheimer's disoase[J].Curr Neurovasc Res,2004,1:317-323.
  • 7[4]Liu B,Hong JS.Role of microglia inflammation-medlated neurodegenerative diseases:mechanisms and stratngies for therapeutic intervention[J].J Pharmacol Exp Ther,2003,304(1):1-7.
  • 8[6]Heneka MT,Sastre M,Dmnitrescu-Ozimek L,et al.Acute treatment with the PPARγagonist pioglitazone and ibuprofen reduces glial inflammation and Aβ1-42 levels in APPV717I transgenic mice[J].Brain,2005,128(6):1442-1453.
  • 9[7]Mattson MP.Apoptosis in neurodegenerative diserders[J].Nat Per Mol Cell Biol,2000,1(2):120.
  • 10[8]Tan J,Town T,Mori T,et al.CD45 opposes beta-amyloid peptide-induced microglial activation via inhibition of p44/42 mitogen-actinated protein kinase[J].Neurosci,2000,20(20):7587.

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基础医学与临床
2004年 第1期

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