一种对血液动力学影响较小的判断犬脑死亡新方法

A method of deciding brain death with less influence on hemodynamics in dog

呼吸暂停试验在临床判定脑死亡诊断过程中起十分关键的作用。据报道 ,传统试验方法可引起严重低血压、肺动脉高压、心律失常等并发症。本研究在脑死亡动物模型中以吸入CO2 提高PaCO2 改进呼吸暂停试验 ,旨在减少对血流动力学的影响。结果表明 ,吸入CO2 法能有效刺激呼吸中枢 ,与传统试验方法比较 ,能显著缩短试验时间 ,对血压、心率影响较小 ,试验过程中血管活性药物的需要量无显著增加。更重要的是未发现肺动脉高压。上述结果提示 ,吸入CO2 法较传统方法更加安全 。

Apnea test plays a very important role in diagnosing brain death. But, conventional method may result in severe complications such as hypotension, pulmonary artery hypertension as well as arrhythmia. This research was aiming to minimizing the complications of apnea test by artificial augmentation of PaCO 2 in dog model of brain death. Our results showed that the modified apnea test is a high reliable method. Compared with the conventional way, it efficiently keeps the circulation stabilization without increasing infusion rate of nor-epinephrine (NE) by significantly shorting the testing time. Notably, pulmonary artery hypertension didn't appear during testing. Our finding indicates that artificial augmentation of PaCO 2 is safer than conventional apnea test.