胃癌患者血清一氧化氮检测的临床意义

CLINICAL SIGNIFICANCE OF SERUM NITRIC OXIDE IN PATIENTS WITH GASTRIC CARCINOMA

目的:探讨血清一氧化氮(sNO)与胃癌临床病理特征的联系。方法:采用硝酸还原酶法检测31 例胃癌患者术前及术后第1 天sNO水平,并与同期13 例慢性萎缩性胃炎患者对比。结果:胃癌患者sNO高于对照组(P<0.05);sNO随临床分期进展而升高(P<0.05);接受根治手术的患者术后较术前下降(P<0.05);接受姑息手术者下降不明显(P>0.05)。结论:sNO与胃癌的临床病理特征有关,术后sNO仍显著增高者需要更积极的治疗。

Objective:To investigate the relationship between serum nitric oxide(sNO)and clinico-pathologial parameters of gastric carcinoma.Methods:The sNO levels were detected in31patients with gastric carcinoma before operation and on the first day after operation respectively by spectrophotometry,and the levels of sNO in13patients with chronic gastritis were detected simultaneously.Results:The levels of sNO in gastric carcinoma patients were higher than those in control group(P<0.05);sNO ascended in ac-cordance with clinical stage(P<0.05);sNO fell on the first day after operation in patients undergoing radical resection(P<0.05),while there was no fall in those undergoing palliative resection(P>0.05).Conclusion:The sNO level is associated with clinco-pathological parameters and contributes to genesis and development of gastric carcinoma.