摘要
本文研究了连翘叶提取物 (FSE)对小鼠氧化损伤的保护作用 ,并对其安全性进行初步评价。结果表明 ,连翘叶提取物可以降低小鼠因四氧嘧啶所致氧化损伤而引起的肝脏、心脏、股四头肌、脑组织、红细胞中MDA、SOD、POD以及小鼠血清中ALT、AST、AKP的异常升高 ,提示FSE对小鼠的氧化损伤有保护作用。小鼠对FSE的最大耐受量为 62 .5 g/kg体重 ,相当于人日常用量 (5 g)的 75 0倍。
In this paper we studied the effects of FSE (extracts of Forsythia suspense leaves) on oxidative lesion induced by alloxan in mice and evaluated the safety of its usage. The results showed that FSE could reduce the abnormal increase of SOD、POD、MDA in liver、heart、brain、 musculus quadriceps femoris tissue 、 red blood cell and ALT、AST、AKP in blood serum induced by oxidative lesion in mice, It showed FSE could protect the oxidative lesion in mice. The maximal tolerance dosage of mice to FSE is 62.5g/kg, as 750 times as daily usage of man(5g).
出处
《中药药理与临床》
CAS
CSCD
2004年第1期18-20,共3页
Pharmacology and Clinics of Chinese Materia Medica
