肝硬克颗粒抗猪血清致大鼠免疫性肝纤维化的实验研究

Experimental study of Ganyingke Granule(肝硬克颗粒) on immunological hepatic injury induced by the serum of pig in rat

肝硬克颗粒能明显降低猪血清诱导的免疫性肝纤维化大鼠血清AST、ALT、HA、LN、PC Ⅲ和肝胶原蛋白含量 ,显著提高血清TP和ALB含量 ,减轻肝细胞坏死 ,显著改善肝功能 ,抑制肝纤维化 ,表明对免疫性肝纤维化有明显抑制作用。

A model of immunological hepatic injury induced by the pig serum was used to investigate the effect of Ganyingke Keli in rat. The results showed that the contents of AST、ALT、HA、LN、PC-Ⅲ and liver collagen in the serum of rat were significantly decreased, the contents of TP、ALB in the serum of rat was obviously increased, the degeneration and necrosis of liver cells was abated, the function of liver was significantly improved, and hepatic fibrosis was inhibited after treating with Ganyingke Keli. It is concluded that Ganyingke Keli has therapeutic effects on immunological hepatic injury induced by the pig serum in rat.