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eIF-4E与肿瘤 被引量：2

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摘要 eIF 4E是最重要的翻译起始因子 ,在真核细胞的蛋白质合成中起重要作用。近年来对eIF 4E的研究主要集中在其对细胞生长分化有关蛋白的调控 ,其与肿瘤发生发展的关系及临床应用价值等方面。
作者 张进安 司履生
机构地区 西安交通大学第一医院内分泌科 西安交通大学肿瘤研究所
出处 《国外医学（生理病理科学与临床分册）》 2004年第1期75-77,共3页 Foreign Medical Sciences(Pathophysiology and Clinical Medicine)
关键词 EIF-4E 肿瘤
分类号 R730.2 [医药卫生—肿瘤]
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参考文献29

  • 1Gao M, Dasgger WR, Rhoads RE, et al. Cloning and characterization of human eIF-4e gene[J]. J Biol Chem.1998,273(8) :4622-4628.
  • 2Pelletier J, Brook JD, Housman DE. et al. Assignment of two of the translation initiation factor-4E genes to human chromosomes 4 and 20[J]. Genomics,1991,10(4) :1079-1082.
  • 3Dostie J, Ferrajuolo M, Pause A, et al. A novel shuttling protein,4E-T, mediates the nuclear import of the mRNA 5'cap-binding protein, elfF-4E[J]. EMBO J, 2000,19(12) :3142-3156.
  • 4Rhoads RE. Regulation of eukaryotic protein synthesis by initiation factors[J]. J Biol Chem, 1993,268(5) :3017-3021.
  • 5Scheper GC, Proud CG. Dose phosphorylation of the cap-binding protein eIfF-4E play a role in translation initiation? [ J ]. Eur J Biochem, 2002,269(22) :5350-5359.
  • 6Raught B,Gingras AC.EIF-4E activity is regulated at multiple levels[J].Int J Biochem Cell Biol, 1999,31 (1) :43-57.
  • 7Mckendrick L, Pain VM, Morley ST, et al. Translation initiation factor 4E[J]. Int J Biochem Cell Biol, 1999,31 (1) :31-35.
  • 8Fingar DC, Salama S, Tsou C, et al. Mammalian cell size is controlled by mTOR and its downstream targets S6K1 and 4EBP1/eIF4E[J]. Genes Dev ,2002,16(12) : 1472-1487.
  • 9Gonzalez YC, Sanchez MV. Pancreastatin, a chromogranin A-derived peptide, activates protein synthesis signaling cascade in rat adipocytes[J]. Biochem Biophys Res Commun, 2002,299 ( 4 ) :525-531.
  • 10Senthil D, Choudhury GG, Abboud HE, et al. Regulation of protein synthesis by IGF-1 in tubular epithelial cells[J]. Am J Physiol Renal Phsio1,2003,283 (6) : F1226-1236.

同被引文献34

  • 1董文汇,孙树军,刘清明.原癌基因eIF4E在恶性肿瘤中表达的研究进展[J].中国医学文摘（肿瘤学）,2004,18(3):229-230. 被引量：1
  • 2刘丽萍,于卉影,马东初.eIF4E的研究进展[J].细胞与分子免疫学杂志,2005,21(B03):118-121. 被引量：6
  • 3李建国.核糖体失活蛋白的研究进展[J].分子植物育种,2005,3(4):566-570. 被引量：28
  • 4Yu-Yang Zhang,Han-Xia Li,Bo Ouyang,Zhi-Biao Ye.Regulation of Eukaryotic Initiation Factor 4E and Its Isoform： Implications for Antiviral Strategy in Plants[J].Journal of Integrative Plant Biology,2006,48(10):1129-1139. 被引量：3
  • 5Nicaise V, German-Retana S,Sanjuan R, et al.. The eukaryotic translation initiation factor 4E controls lettuce susceptibility to the Potyvirus lettuce mosaic virus [J]. Plant Physiology, 2003, 132:1272-1282.
  • 6Robaglia C, Caranta C. Translation initiation factors: a weak link in plant RNA virus infection[J]. Trends in Plant Science, 2006, 11(1): 40-45.
  • 7Goldbach R, Bucher E, Prins M. Resistance mechanisms to plant viruses: an overview[J]. Virus Reasearch, 2003, 92: 207 -212.
  • 8Soonaar J L, Burch-Smith T M, Dinesh-Kumar S P, et al.. Mechanisms of plant resistance to viruses [ J ]. Nature Reviews Microbiology, 2005,3:789 -798.
  • 9Gao Z, Johansen E, Eyers S, et al.. The potyvirus recessive resistance gene, sbml, identifies a novel role for translation initiation factor eIF4E in cell-to-cell trafficking[J]. The Plant Journal, 2004, 40:376-385.
  • 10Johansen E, Lund O S, Hjulsager C K, et al.. Recessive resistance in Pisum sativum and potyvirus pathotype resolved in a gene-for-cistron correspondence between host and virus [ J ]. Journal of Virology, 2001,75(14) : 6609 -6614.

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国外医学（生理病理科学与临床分册）
2004年 第1期

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