丙型肝炎病毒核心蛋白(HCV核心)与NF-κB信号通路
摘要
NF κB信号通路与炎症、细胞增殖、凋亡及细胞的恶性转化密切相关 ,在肝疾病的发生发展过程中具有重要作用 ;丙型肝炎病毒 (HCV)感染常见 ,是慢性肝炎和肝细胞癌 (HCC)的主要致病因素 ;HCV通过其病毒蛋白干预细胞的正常功能 。
出处
《国外医学(生理病理科学与临床分册)》
2004年第1期101-103,共3页
Foreign Medical Sciences(Pathophysiology and Clinical Medicine)
参考文献23
-
1Ray RB, Meyer K, Ray R. Hepatitis C virus core protein promotes immortalization of primary human hepatocytes[J]. Virology ,2000,271 ( 1 ) :197-204.
-
2Moriya K, Fujie H, Shintani Y,et al. The core protein of hepatitis C virus induces hepatocellular carcinoma in transgenic mice [ J ].Nat Med,1998,4(9) :1065-1067.
-
3Marusawa H, Hijikata M, Chiba T, et al. Hepatitis C virus core protein inhibits Fas- and tumor necrosis factor alpha-mediated apoptosis via NF-kappaB activation[J]. J Virol, 1999,73(6) :4713-4720
-
4Lai MM. Hepatitis viruses and signal transduction: true to the core?[J]. Hepatology,2000,32(2) :427-429.
-
5Zhu N, Khoshnan A, Schneider R, et al. Hepatitis C virus core protein binds to the cytoplasmic domain of tumor necrosis factor(TNF) receptor 1 and enhances TNF-induced apoptosis[J]. J Virol, 199872(5) :3691-3697.
-
6Kato N, Yoshida H, Kioko Ono-Nita S ,et al. Activation of intracellular signaling by hepatitis B and C viruses : C-viral core is the most potent signal inducer[J]. Hepatology,2000,32(2) :405-412.
-
7Yasui K, Wakita T, Tsukiyama-Kohara K, et al. The native form and maturation process of hepatitis C virus core protein [ J ]. J Virol, 1998,72 (7) :6048-6055.
-
8Lu W, Struhecker A, Ou Jh JH. Post-translational modification of the hepatitis C virus core protein by tissue transglumminase[ J ]. J Biol Chem,2001,276(51) :47993-47999.
-
9Watashi K, Hijikata M, Marusawa H, et al. Cytoplasmic localization is important for transcription factor nuclear factor-kappa B activation by hepatitis C virus core protein through its amino terminal region[J]. Virology, 2001,286(2) :391-402.
-
10Zhu N, Ware CF, Lai MM. Hepatitis C virus core protein enhances FADD-mediated apoptosis and suppresses TRADD signaling of tumor necrosis factor receptor [ J ]. Virology, 2001, 283 ( 2 ) : 178-187
-
1罗莹,赵文霞.慢性丙型肝炎合并脂肪肝的中西医研究进展[J].中医研究,2016,29(5):76-78. 被引量:3
-
2朱峰,钱家鸣,等.丙型肝炎病毒核心蛋白细胞内信号传导途径的探讨[J].胃肠病学,2002,7(B11):48-48.
-
3刘娇,唐霓.丙型肝炎病毒核心蛋白的研究进展[J].中华传染病杂志,2011,39(3):185-188.
-
4李建蓉,公瑞煜.丙型肝炎病毒核心蛋白生物学功能研究进展[J].大理医学院学报,2001,10(1):57-59. 被引量:2
-
5刘念,李凡.丙型肝炎病毒核心蛋白与慢性感染[J].国外医学(微生物学分册),2003,26(6):4-5.
-
6孙英梅,许国蓉(综述),陶剑平(审校).丙型肝炎病毒核心蛋白引发肝脂肪变性机制的研究进展[J].国际病毒学杂志,2009,16(6):167-170. 被引量:5
-
7刘锦锋,刘敏,赵英仁.丙型肝炎病毒核心蛋白致肝炎慢性化机制[J].国外医学(内科学分册),2006,33(8):362-365.
-
8王文勇,张志培,黄立军,马福成,赵一岭.丙型肝炎病毒核心蛋白对突变p53和Bcl-2表达的影响及意义[J].中华肝脏病杂志,2005,13(2):148-149. 被引量:4
-
9刘敏,成军,张树林.丙型肝炎病毒核心蛋白与白介素-2启动子的调节[J].世界华人消化杂志,2004,12(4):940-943.
-
10曹统,王义国.丙型肝炎病毒核心蛋白对人源性肝细胞凋亡的影响[J].山东大学学报(医学版),2014,52(3):37-39. 被引量:1