Synthesis of Nucleoside Derivatives Containing Benzophenoxazinone Moiety
Synthesis of Nucleoside Derivatives Containing Benzophenoxazinone Moiety
摘要
Two new nucleoside derivatives containing benzophenoxazinone moiety were synthesized. Their luminescence spectra show that they have strong near infrared fluorescence. Our study provides a new method for direct introduction of near infrared fluorescent probe to bioactive molecules.
Two new nucleoside derivatives containing benzophenoxazinone moiety were synthesized. Their luminescence spectra show that they have strong near infrared fluorescence. Our study provides a new method for direct introduction of near infrared fluorescent probe to bioactive molecules.
参考文献14
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7[7]1H-NMR (200 MHz) data for 6a (DMSO-d6, δ ppm): 1.30-1.52 (m, 9 H, -CH2CH3, -C(CH3)2), 2.61-2.73 (m, 2 H, -NCH2CH2-), 3.05 (s, 3 H, -NCH3), 3.83-3.95 (m, 2 H, -NCH2CH2-), 4.15-4.42 (m, 5 H, -OCH2CH3, 2×H-5′, H-4′), 4.73-4.82 (m, 1 H, H-3′), 5.04-5.14 (m, 1 H, H-2′), 5.62 (d, 1 H, J =7.6 Hz, base H-5), 5.70 (s, 1 H, base H-3), 5.75 (d, 1 H, J =2.3 Hz, H-1′), 6.68 (d, 1 H, J =2.0 Hz, H-8), 6.98 (dd, 1 H, J =9.7, 2.2 Hz, H-10), 7.66-7.82 (m, 4 H, H-2, H-3, H-11,base H-6), 8.14 (d, 1 H, J =7.5 Hz, H-4), 8.60 (d, 1 H, J =7.3 Hz, H-1); MS (FAB) data for 6a (m/z): 687.3 (M+1).
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