并发严重循环充血时急性肾小球肾炎的心肌酶学改变临床分析

Clinical analysis of myocardial enzymogram in acute glomerulonephritis with severe circulatory congestion

目的 :研究并发严重循环充血时急性肾小球肾炎 (AGN)的心肌酶学改变及其临床意义。方法 :对 5 2例无并发症的AGN和 1 7例并发严重循环充血状态的AGN患儿血中肌酸激酶 (CK)、肌酸激酶同功酶 (CK -MB)、乳酸脱氢酶 (LDH)α -羟丁酸脱氢酶 (αHBDH)和天冬氨酸转氨酶 (AST)的含量进行测定。结果 :无并发症的AGN患儿CK、CK -MB、LDH、αHBDH、AST与正常健康儿童对照均无显著性差异 (P >0 .0 5 )而并发严重循环充血状态的AGN患儿CK、LDH及AST均明显高于正常健康儿童 ,而CK -MB及αHBDH仍在正常范围。结论 :测定血清心肌酶对判断AGN是否并发严重循环充血有参考价值。

Objective: To study the significance of myocardial enzymogram in acute glomerulonephritis with severe circulatory congestion.Method: Serum creatine kinase(CK),CK-MB,lactic dehydrogenase(LDH),α-hydroxybutyrate dehydrogenase(αHBDH) and aspartate aminotransferase (AST) were measured in 52 acute glomerulonephritis cases without complication and 17 cases with severe circulatory congestion. Result: The CK,CK-MB.LDH. αHBDH and AST levels in noncomplicated group were within normal range. There was no significant difference (P>0.05) compared with normal children. And the CK、LDH and AST levels in complicated group were significantly higher than those in normal children, while the CK-MB and αHBDH levels were still normal.Conclusion: Myocardial enzyme measurement is significant in diagnosing acute glomerulonephritis complicated with severe circulatory congestion.