急性心肌梗死患者血清PⅠCP、PⅢNP的检测及临床意义

Determined and clinical significance of serum PⅠCP and PⅢNP in patients with acute myocardial infarction

目的 :研究急性心肌梗死 (AMI)患者发病后 1个月内血清Ⅰ型前胶原羧基端肽 (PⅠCP)和Ⅲ型前胶原氨基端肽 (PⅢNP)水平的变化 ,探讨其临床意义。方法 :采用放射免疫分析法测定 3 8例急性心肌梗死发病后d2、d7、d1 4及d2 8血清PⅠCP和PⅢNP的水平。结果 :AMI患者发病后d7、d1 4和d2 8血清PⅠCP和PⅢNP水平分别与对照组比较均明显升高 (P <0 .0 0 1 )。结论 :AMI患者血清PⅠCP和PⅢNP含量明显升高并持续 1个月以上 ,反映AMI后心肌间质胶原的合成增加 ,降解相对不足而致心肌纤维化。

Objective: To investigate the changes of levels of carboxyterminal propeptide of typeⅠ procollagen (PⅠCP) and aminoterminal propeptide of type procollagen Ⅲ(PⅢNP) in patients with acute myocardial infarction(AMI) within one month after infracting, and to study those clinical significance. Methods: The serum levels of PⅠCP and PⅢNP in 38 cases AMI patients on the 2th,7th,14th and 28th days and 25 cases healthy control were measured by radioimmunoassays . Results: Compared to the control group , the serum levels of PⅠCP and PⅢNP in AMI group were significantly increased on the 7th, 14th and 28th days(P<0.001). Conclusions: The serum levels of PⅠCP and PⅢNP increased significantly and elevatly until the 30 days after AMI in patients. Myocardial fibrosis may due to the excessive synthesis and insufficient degradation of collagen.