溶液温度对失血性休克兔中心温度的影响

Influence of Infusion Fluids Temperatures on Core Body Temperature of Rabbits With Hemorrhagic Shock

[目的 ]探讨采用不同温度液体复苏时对失血性休克兔中心温度的影响 ,筛选较为适宜的抗休克补液温度。 [方法 ]将实验兔 (n =3 0 )随机分为假手术组 (n =7)、温热组 (n =8)、常温组(n =7)、低温组 (n =8)。温热组、常温组、低温组复制兔失血性休克模型后 ,给予 3倍失血量的平衡液及自体血复苏 ,液体温度分别控制在3 9 .5℃± 1.3℃、2 0 .6℃±1.3℃、10 .7℃± 1.6℃。选择休克前 (T1)、休克模型形成后 3 0min (T2 )及液体复苏后 1h(T3 )、2h(T4)、4h(T5)时间点观察中心温度的变化。 [结果 ]液体复苏后1h、2h、4h温热组中心温度保持相对稳定 ,而常温组、低温组下降 ,差异有统计学意义 ;常温组与低温组间差异无统计学意义。 [结论

Objective: to probe into the influence of infusion fluids of different temperature in resuscitation on the core temperature of rabbits with hemorrhagic shock, to select a suitable infusion fluids temperature for anti-shock therapy of rabbits. Method: a total of 30 rabbits were divided into 4 groups randomly as pseudo-surgery (n=7), warm (n=8), normal temperature (n=7), and low temperature (n=8). Rabbits of pseudo-surgery group were just prepared as the other three groups and had not lead to shock. Hemorrhagic shock model were prepared in warm, normal, and low temperature group rabbits, then Ringer's lactate and auto-blood of three times of their blood loss were infused for resuscitation. And infusion fluids temperatures were controlled at 39.5 ℃±1.3 ℃,20.6 ℃±1.3 ℃,10.7 ℃±1.6 ℃ respectively. Core temperatures changes of all subjects on different time points as before shocked (T 1), 30 min after shocked (T 2), 1h after fluids infusion (T 3), 2h (T 4), and 4h (T 5) after fluids infusion were measured respectively. Results: core temperatures of warm group rabbits had kept relatively stable 1 h,2 h,and 4 h after fluids infusion. However core temperature of either normal or low temperature group rabbits were decreased to some extent. There were statistical significant differences between the 3 groups. But there was no statistical significance between normal temperature and low temperature groups. Conclusion: warm fluids infusion could keep core temperature of hemorrhagic shock rabbits relatively stable.