初发慢性髓系白血病bcr/abl融合基因转录子与临床关系的观察

Clinical features of bcr/abl fusion transcripts in novel chronic myelogenous leukemia.

目的 研究初发慢性髓系白血病bcr/abl融合基因转录子类型与临床关系。方法 使用RT PCR对 5 1例初发CML患者进行bcr/abl融合基因转录子检测。结果 b3a2型患者血小板数高于b2a2型患者 ,但b3a2型患者WBC数低于b2a2型患者 (P <0 .0 5 ) ;血红蛋白浓度与b2a2型患者比较无差异 (P >0 .0 5 ) ;b3a2型和b2a2型患者比较AKP和Ph1染色体比例无差异 (P >0 .0 5 ) ;M bcr/abl阳性患者伴m bcr/abl阳性率为 47 0 % ,其中b3a2型患者有m bcr/abl融合基因转录子 14例 ,b2a2型患者有 10例。结论 b3a2型CML患者初发时更易有血小板升高表现 ,但b2a2型患者更易有WBC数升高的表现 ,较多的初发CML患者同时伴有m bcr/abl阳性。

Objective To study the relationship between the type of bcr/abl fusion transcripts and the clinic featurs in novel chronic myelogenous leukemia.Methods we detected bcr/abl fusion gene by RT-PCR.Results The platelet count in patients with b3a2 was more than that in patients with b2a2,but the WBC count in patient with b3a2 was lower than that in patients with b2a2 (P<0.05).At the same time,the concentrations of hemoglobin had no difference between the two groups. ALP and Ph 1 chromosome also had no difference.The positive rate of M-bcr/abl fusion positive patients with m-bcr/abl fusion was 47.0%,and 14 patients with b3a2 and 10 patients with b2a2 were included.Conclusion Novel CML patients with b3a2 tend to have higher platelet count than patients with b2a2,but patients with b2a2 have a higner WBC count.Most of the patients in CML are accompanied with the positive rate of m-bcr/abl fusion gene transcripts.