恶性淋巴瘤中EB病毒感染的病例-对照研究

Case-control study of the infections of Epstein-Barr virus in malignant lymphomas.

目的 探讨四川地区恶性淋巴瘤 (ML)中EB病毒感染的情况及其临床意义。方法 本研究采用以医院为基础的病例 对照研究的设计方案。病例组 :病理检查确诊的结内、外ML 80例。对照组 :同期病理组织活检证实的非肿瘤病例 80例。EB病毒 (EBV)检测用病理组织采用EBER ISH法。结果 EBV阳性率ML组 72 5 % ( 5 8/ 80 ) ,对照组 7.5 %( 6/ 80 ) ,OR =7.2 6,95 %CI :13 .2 76～ 10 6.62 4,P =0 .0 0 0 1。结论 本地区EBV感染与ML发病有明显相关性。

Objective To investigate the infectious rate of Epstein-Barr virus(EBV) in malignant lymphomas(ML)and the relationship between the incidence of ML and the infection of EBV in Sichuan province.Methods A hospital-based case-control study was Conducted.Case group was diagnosed as ML by pathological examination,which included 80 patients.Control group was composed of 80 subjects with non-malignant diseases demonstrated by pathological examination at the same time.The EBV was confirmed by the EBER in situ-hybridization of pathological tissue.Results The positive rate of EBV in ML group was 72.5%(58/80)and that of control group was 7.5%(6/80).The difference between these two groups showed a statistical significance by logistic regression analysis(OR=7.26,95%CI:13.276～106.624,P=0.0001).Conclusion The incidence of ML indicates a significant association with the infection of EBV in Sichuan.