四种类型尿结石与尿液成分的关系

Relations between four types of urolith and urine component

目的 探讨四种类型结石与 2 4h尿液成分之间的关系。方法 体外震波碎石术 (ESWL)后 ,取石做红外光谱分析 ,检测结石成分 ,确定结石类型 ;用生化方法检测结石成分。结果 红外光谱分析四种类型结石 :一水草酸钙 ,二水草酸钙 ,草酸钙 +羟基磷灰石 ,尿酸。尿液成分分析与对照组比较 ,含荜酸钙的结石类型 ,尿总钙含量显著减少 (P <0 .0 1) ,但一水荜酸钙与二水草酸钙结石患者尿量显著减少 ,而草酸钙 +羟基磷灰石这种复合成分的结石患者pH值偏高 (P <0 .0 5 ) ,尿枸橼酸含量显著偏低 (P <0 .0 1) ,这二种成分变化有别于前者 ;尿酸结石中所有成分都显著减少 (P <0 .0 1)。尿酸结石与草酸钙 +羟基磷灰石结石比较 ,除尿磷、尿枸橼酸无明显差异外 ,其他成分都有显著性差异。结论 检测 2 4h尿液成分的变化对推断结石类型。指导临床治疗与预防有应用意义。

Objective:To explore the relations between four types of urolith and urine ingredient of 24 hours. Methods:The component of urolith got from ESWL through infrared ray spectrum to define the types of urolith. The urine component was measured by biochemical methods.Results: There were four kinds of' urolith: monohydrate calcium oxalate,dihydrate calcium oxalate, calcium oxalate with hydroxyapatite and uric acid.Compared to the control group, in the specimens of urolith contained calcium oxalate the content, of total Calcium decreased significantly (P<0.01), but the amount of urine in the cases with monohydrate calcium oxalate and dehydrate calcium oxalate reduced significantly (P<0.01); PH value of suffer was higher in the complex of monohydrate calcium oxalate and hydnxy apatite (P<0.05), the components of these two are different from before,the component of uric acid lowered significantly.(P<0.01).Conclusions:Determination of the changes in urine ingredient in 24 hours has clinical significance in helping diagnose types of urolith and in the treatment and prevention of urolithiasis.