空蝶鞍综合征合并不孕的诊断与治疗

Diagnosis and treatment of empty sella syndrome with infertility

目的探讨空蝶鞍综合征合并不孕的诊断与治疗。方法回顾性分析5例确诊为空蝶鞍综合征合并不孕患者的临床资料。结果5例患者,平均年龄27.2岁。均表现为闭经、泌乳、血卵泡刺激素(FSH)、黄体生成素(LH)较低、血泌乳素(PRL)高。MRI检查示空蝶鞍。用雌二醇周期治疗并每日服用溴隐停3个月,第4个月用垂体促性腺激素(HMG)诱发排卵1个周期。排卵率60%,受孕率20%。结论空蝶鞍综合征伴不孕患者排卵率和受孕率较低,可能是长期低雌激素状态和持续性高PRL所致,治疗效果不佳。

ObjectiveTo investigate diagnosis and treatment of empty sella syndrome (ESS) withinfertility.MethodsThe clinical data of 5 cases of ESS with infertility were analyzed retrospectively.ResultsOf 5pa-tients, the average age was 27.2. The clinical manifestations were amenia,lactation,decreased FSH and LH,increased PRL. 5patients were confirmed to be ESS by MRI. The rate of ovulation was 60% and the rate of pregnancy was 20%.ConclusionsThe rates of ovulation and pregnancy decrease in ESS with infertility. It is probably due to long-term lowestrogen state and persistent high PRL level.