内镜活检和手术切除直肠癌组织的微血管计数比较

Comparative Analysis of Microvessel Count between Endoscopic Biopsy and Surgery in Rectal Cancer Tissue

目的 :检验以内镜活检标本作为测定直肠癌微血管计数 (MVC)材料的可靠性 ,探索早期获得MVC的方法。方法 :用免疫组化法测定 86例内镜活检阳性的直肠癌组织的MVC ,并与相应的手术切除标本的MVC进行比较和相关分析。结果 :内镜活检组的平均MVC为 2 8 6 9± 5 16 ,手术切除组为 2 7 92± 4 85。经统计学分析 ,两组MVC无统计学意义 (P >0 2 0 ) ,但有很好的相关性 (r=0 78)。结论 :用内镜活检直肠癌组织可替代手术切除标本作测定MVC的材料 ,不仅其可靠性大 ,而且能够在术前获取MVC结果 ,为恰当制定直肠癌的治疗方法。

Objective: To evaluate the reliability of microvessel count (MVC) of endoscopic biopsy of the rectal cancer, and study the method to get rectal cancer tissue preoperatively. Method: MVC of rectal cancer was determined by immunohistochemical method in 86 endoscopic samples and corresponding surgical samples.Results:The mean MVC in endoscopic samples was 28.69±5.16,27.92±4.85 in surgical samples.There was no significant difference (P>0.20).The MVC of endoscopic samples was highly correlated with the MVC of surgical samples(r=0.78). Conclusion:The endoscopic biopsy is a reliable method to get MVC of rectal cancer preoperatively, and the preoperative MVC is an important reference to envaluate the tumor stage and prognosis,and to make a right treatment method for carcinoma of the rectum.