摘要
以健康人群为对照 ,Graves病患者分成甲巯咪唑 (MMI)组 (MMI 2 0mg/d)和甲氨蝶呤(MTX)组 (MMI 2 0mg/d +MTX 7.5mg/w ) ,测得患者组CD4、Th增高而Tc低下 ,治疗 6周后该异常虽无明显改变 ,可溶性白细胞介素 2 (sIL 2 )受体和甲状腺自身抗体下降 ,但组间差异无显著性。提示Graves病治疗前存在免疫异常 ,MMI及其加用MTX治疗 6周使sIL 2受体及甲状腺自身抗体明显下降 ,加用MTX未见对免疫功能的影响优于单用MMI。
Observation revealed the abnormalities (increased CD 4 and Th, decreased Tc) in patients of Graves′ disease, and these abnormalities were not significantly adjusted after 6 weeks of treatment with methimazole (MMI), or with MMI and methotrexate (MTX), though the soluble interleukin-2 receptor and thyroid autoantibodies slightly decreased in both groups. However, the addition of MTX did not show any better effects than MMI alone in the treatment.
出处
《中华内分泌代谢杂志》
CAS
CSCD
北大核心
2003年第2期101-102,共2页
Chinese Journal of Endocrinology and Metabolism
