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C肽对链脲佐菌素糖尿病大鼠的糖尿病肾病的干预作用 被引量:18

Intervention of C-peptide on diabetic nephropathy in streptozotocin induced diabetic rats
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摘要 以链脲佐菌素制备糖尿病大鼠模型 ,造模后C肽治疗 8周 ,以肾小球体积及肾小球截面积为指标 ,均较高糖对照组下降 ,显示对糖尿病肾病有保护作用。 Diabetic rats was preparated by streptozotocin. After establishment of diabetic model, treatment with C-peptide for 8 weeks shows protective effect on diabetic nephropathy. The effect manifested as reduced glomerular volume and reduced cross-sectional glomerular area when compared with untreated rats.
出处 《中华内分泌代谢杂志》 CAS CSCD 北大核心 2003年第2期143-144,共2页 Chinese Journal of Endocrinology and Metabolism
基金 上海市现代生物与新药产业发展基金资助 (98431 91 2 0 )
关键词 C肽 链脲佐菌素 大鼠 糖尿病肾病 药物治疗 并发症 Diabetic nephropathies C-peptide Streptozocin Rats, Sprague-Dawley
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  • 1Rudolf W, Bilous S, David ER, et al. Mean glomerular volume and rate of development of diabetic nephropathy. Diabetes, 1989,38:1142-1147.
  • 2Osterby R, Parving HH, Hommel E, et al. Glomerular structure and function in diabetic nephropathy. Early to advanced stage. Diabetes, 1990,39:1057-1064.
  • 3Sjoquist M, Huang W, Johansson B. Effects of C-peptide on renal function at the early stage of experimental diabetes. Kidney Int, 1998,54:758-764.
  • 4Johansson BL, Brog K, Fernqvist-Forbes E, et al. Beneficial effects of C-peptide on incipient nephropathy and neuropathy in patients with type 1 diabetes mellitus. Diabet Med, 2000,17:181-189.

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