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2型糖尿病患者外周血单个核细胞中醛糖还原酶mRNA水平与糖尿病肾病危险性的关系 被引量：2

Relationship between aldose reductase gene expression in peripheral blood mononuclear cells and the risk of diabetic nephropathy in type 2 diabetic patients
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摘要 以RT PCR法检测外周血单个核细胞 (PBMC)中醛糖还原酶 (AR)mRNA水平。 2型糖尿病患者的PBMCARmRNA水平与尿白蛋白排泄率呈正相关 ,提示AR活性与糖尿病肾病的发病机制有关。 Aldose reductase (AR) mRNA level in peripheral blood mononuclear cells was assayed by RT-PCR. There was a positive correlation between PBMC AR mRNA level and urinary albumin excretion rate in type 2 diabetic patients. The result suggests that AR activity is related to the pathogenesis of diabetic nephropathy.
作者 何敏慧 李红 李成江
机构地区 浙江大学附属第一医院内分泌科
出处 《中华内分泌代谢杂志》 CAS CSCD 北大核心 2003年第6期467-469,共3页 Chinese Journal of Endocrinology and Metabolism
基金 浙江省教育厅科研基金资助项目 (982 0 1 3) 浙江省卫生厅科研基金资助项目 (98A0 1 3)
关键词 2型糖尿病 外周血 单个核细胞 醛糖还原酶 MRNA水平 糖尿病肾病 危险性 尿白蛋白排泄率 Aldose reductase Diabetes mellitus, non-insulin dependent Diabetic nephropathies Urinary albumin excretion rate
分类号 R587.2 [医药卫生—内分泌] R692 [医药卫生—泌尿科学]
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参考文献6

  • 1Robbins DC;Knowler WC;Lee ET.Regional differences in albuminuria among American Indians: an epidemic of renal disease[J],1996.
  • 2Seaquist ER;Goetz FC;Rich S.Familial clustering of diabetic kidney disease: evidence for genetic susceptibility to diabetic nephropathy[J],1989.
  • 3Imperatore G;Hanson R L;Pettitt D J.Sib-pair linkage an alysis for susceptibility genes for microvascular complications among Pima India ns with type 2 diabetes[J],1998(5).
  • 4Hasegawa G;Obayashi H;Kitamura A.Increased levels of aldose reductase in peripheral mononuclear cells from type 2 diabetes patients with microangiopathy[J],1999.
  • 5Vallabh OS;Marina S;Jovanka N.Z-2 microsatellite allele is linked to increased expression of the aldose reductase gene in diabetic nephropathy[J],1998.
  • 6刘丽梅,项坤三,郑泰山.醛糖还原酶基因多态性与糖尿病微血管并发症的相关性研究[J].中华内分泌代谢杂志,1999,15(5):263-266. 被引量：16

二级参考文献2

  • 1Dr. C. Nishimura,T. Saito,T. Ito,Y. Omori,T. Tanimoto. High levels of erythrocyte aldose reductase and diabetic retinopathy in NIDDM patients[J] 1994,Diabetologia(3):328～330
  • 2Alexander Graham,Paul Heath,John E. N. Morten,Alexander F. Markham. The human aldose reductase gene maps to chromosome region 7q35[J] 1991,Human Genetics(5):509～514

共引文献17

同被引文献32

  • 1董凤芹,李红,蔡卫民,陶君,李群,阮昱,郑芬萍,张哲.Effects of pioglitazone on expressions of matrix metalloproteinases 2 and 9 in kidneys of diabetic rats[J].Chinese Medical Journal,2004(7):1040-1044. 被引量：8
  • 2陆颖理,张丽,朱岚,赵江波,吴晖,王宁荐,王雪芳,俞丹璐.糖尿病大鼠心肌超微结构改变及过氧化物酶体增殖激活受体gamma配体对其作用的研究[J].浙江大学学报（医学版）,2006,35(3):245-250. 被引量：8
  • 3Cox SL. Rosiglitazone maleate/metformin hydrochloride: a new formulation therapy for type 2 diabetes[J]. Drugs Today(Barc),2004,40(7):633-643.
  • 4Mooradia AD, Thurman JE.Drug therapy of postprandial hyperglycaemia[J].Drugs,1999,57(1):19-29.
  • 5Rendell M.The role of sulphonylureas in the management of type 2 diabetes mellitus[J]. Drugs, 2004,64(12):1339-1358.
  • 6Chun GM, Kourides I, Canovatchel W, et al. Pharmacokinetics and pharmacodynamics of extended-release glipizide GITS compared with immediate-relase glipizide in patients with type Ⅱ diabetes mellitus[J]. J Clin Pharmacol,2002, 42(6):651-657.
  • 7Frey N, Laveille C, Paraire M, et al. Population PKPD modeling of long-term hypoglycaemic effect of gliclazide given as a once-a-day modified release(MR) formulation[J]. Br J Clin Pharmacol,2003, 55(2):147-157.
  • 8Fritsch A, Schweitzer MA, Haring HU, et al. Glimepiride combined with morning insulin glargine, bedtime neutral protamine hagedorn insulin, or bedtime insulin glargine in patients with type 2 diabetes.A randomized,controlled trial[J]. Ann Intern Med,2003,138(12):952-959.
  • 9Graul A, Castaner J.Repaglinide[J].Drugs Future,1996,21(7):694.
  • 10Jones RB, Dickinson K, Anthony DM, et al. Evaluation of BTS67582,a novel antidiabetic agent, in normal and diabetic rats[J]. Br J Pharmacol,1997,120(6):1135.

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中华内分泌代谢杂志
2003年 第6期

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