三维适形放射治疗脑胶质瘤术后残存灶近期疗效分析

3-D Conformal Radiation Therapy for Postoperation Remnant Gliomas: A Clinical Phase ⅠTrial

目的 :探讨增大分割剂量三维适形放射治疗 (3D CRT)脑胶质瘤术后残存灶的近期疗效及早期并发症的发生率。方法 :15例脑胶质瘤进入三维放射治疗组 ,其中星形细胞瘤Ⅰ～Ⅱ级 5例 ,Ⅲ级 7例 ,Ⅳ级 3例。 2～ 3Gy 次 ,1次 d ,5次 周 ,总剂量 5 1～ 6 0Gy。结果 :除 1例生存 10个月死于局部复发外 ,其余全部生存 6个月以上。其中 5例接受 3Gy分割量 ,17次照射的患者生存 11个月以上 ,无放射性脑损伤发生。结论 :大分割三维适形放射治疗脑胶质瘤残存灶患者有较好的近期疗效 ,无早期并发症 。

Objective To evaluate the acute side effects and efficacy of three dimensional conformal radiotherapy(3D CRT) for postoperation remnant gliomas.Methods Fifteen patients with remnant gliomas after their operation received 3D CRT.Among them,5 cases were in astrocytoma grade Ⅰ-Ⅱ,7 cases in grade Ⅲ,3 cases in grade Ⅳ.The total irradiation dose ranging from 51 Gy to 60 Gy was delivered at 2-3 Gy once daily,5 day per week.Results One patient died of local failure in 10 months,others survived up to now.Five patients with grade Ⅲ-Ⅳ survived more than 11 months and were treated with 3 Gy per fraction,five fraction per week.Radiation brain injury and acute side effects were not found.Conclusions High dose fraction 3D conformal radiotherapy was an effective and feasible approach to postoperation remnant gliomas with good responses and without any early serious complications.However,long term survival will be further studied. China J Cancer Prev Treat,2003,10(5):501-502