Application of autologous tumor cell vaccine and NDV vaccine in treatment of tumors of digestive traet

AIM. TO treat patients with stage I-IV malignant tumors of digestive tract using autologous tumor cell vaccine and NDV(Newcastle disease virus) vaccine, and observe the survival period and curative effect.METHODS: 335 patients with malignant tumors of digestive tract were treated with autologous tumor cell vaccine and NDV vaccine. The autologous tumor cell vaccine received were assigned for long-term survival observation. While these failed to obtain the autologous tumor tissue were given with NDV vaccine for a received short-term observation on curative effect.RESULTS: The colorectal cancer patients treated with autologous tumor cell vaccine were divided into two groups:the controlled group (subjected to resection alone) (n=257),the vaccine group (subjected to both resection and immunotherapy) (n=310). 25 patients treated with NDV immunotherapy were all at stage IV without having resection.In postoperation adjuvant therapy patients, the 5, 6 and 7-year survival rates were 66.51%, 60.52 %, 56.50 %respectively; whereas in patients with resection alone, only 45.57 %, 44.76 % and 43.42 % respectively. The average survival period was 5.13 years (resection alone group 4.15 years), the median survival period was over 7 years (resection alone group 4.46 years). There were significant differences between the two groups. The patients treated with resection plus vaccine were measured delayed-type hypersensitivity (DTH) reactions after vaccination, (indurative scope >5 mm).The magnitude of DTH was related to the prognosis. The 5-year survival rate was 80 % for those with indurations greater than 5 mm, compared with 30 % for those with indurations less than 5 ram. The 1-year survival rate was 96 % for 25 patients treated with NDV immunotherapy. The total effective rate (CR+PR) was 24.00 % in NDV immunotherapy; complete remission (CR) in 1 case (4.00 %), partial remission (PR) in 5 cases (20.00 %), stabilizedin in 16 cases (64.00 %),progression (PD) in 1 case (4.00 %). After NDV vaccine immunotherapy, the number of NK cell increased and immune function imporved obviously.CONCLUSION: The autologous tumor cell vaccine and NDV vaccine can prolong the patients' life. NDV vaccine is notably effective for short-term with promotion of quality of life and can be used whenever necessary with good prospects.

AIM;To treat patients with stage I-IV malignant tumors of digestive tract using autologous tumor cell vaccine and NDV (Newcastle disease virus)vaccine,and observe the survival period and curative effect. METHODS:335 patients with malignant tumors of digestive tract were treated with autologous tumor cell vaccine and NDV vaccine.The autologous tumor cell vaccine received were assigned for long-term survival observation.While these failed to obtain the autologous tumor tissue were given with NDV vaccine for a received short-term observation on curative RESULTS:The colorectal cancer patients treated with autologous tumor cell vaccine were divided into two groups: the controlled group(subjected to resection alone)(n=257), the vaccine group(subjected to both resection and immunotherapy)(n=310).25 patients treated with NDV immunotherapy were all at stage IV without having resection. In postoperation adjuvant therapy patients,the 5,6 and 7- year survival rates were 66.51%,60.52 %,56.50 % respectively;whereas in patients with resection alone,only 45.57 %,44.76 % and 43.42 % respectively.The average survival period was 5.13 years(resection alone group 4.15 years),the median survival period was over 7 years(resection alone group 4.46 years).There were significant differences between the two groups.The patients treated with resection plus vaccine were measured delayed-type hypersensitivity (DTH)reactions after vaccination,(indurative scope >5 mm). The magnitude of DTH was related to the prognosis.The 5- year survival rate was 80 % for those with indurations greater than 5 mm,compared with 30 % for those with indurations less than 5 mm.The 1-year survival rate was 96 %for 25 patients treated with NDV immunotherapy.The total effective rate(CR+PR)was 24.00 % in NDV immunotherapy;complete remission(CR)in 1 case(4.00 %),partial remission(PR)in 5 cases(20.00 %),stabilizedin in 16 cases(64.00 %), progression(PD)in 1 case(4.00 %).After NDV vaccine immunotherapy,the number of NK cell increased and immune function imporved obviously CONCLUSION: The autologous tumor cell vaccine and NDV vaccine can prolong the patients' life. NDV vaccine is notably effective for short-term with promotion of quality of life and can be used whenever necessary with good prospects.