p16蛋白和Ki-67抗原在人脑胶质瘤中的表达及其意义

Expression and significance of p16 protein and Ki-67 antigen in brain glioma

目的 研究 p16蛋白及Ki 6 7抗原在人脑胶质瘤中的表达情况。方法 采用免疫组化方法检测 5 0例胶质瘤中 p16蛋白及Ki 6 7抗原的表达情况。结果 随着胶质瘤病理级别的升高p16蛋白的表达率逐渐降低 ,I IV级阳性率分别为 75 .0 % ,6 6 .7% ,4 1.7% ,2 5 .0 % ,低度恶性组 (I II级 )与高度恶性组 (III IV级 )差异有显著性 (P <0 .0 5 )。p16蛋白与Ki 6 7抗原的表达存在负相关 (r=- 0 .4 73P <0 .0 1)。结论 p16蛋白及Ki 6 7抗原的表达对分析、判断胶质瘤分级的适用性及恶性转化具有一定意义。

ObjectiveTo detect the expression of p16 protein and Ki-67 antigen in human brain glioma. Methods The expression of p16 protein and Ki-67 antigen were observed by immunohistochemical method in 50 formalin-fixed paraffin embedded glioma sections. Results Expression of p16 protein significantly decreased with the increase of grades of glioma malignancy. The levels of p16 deletion between low malignant group(I-II) and high maligant group(III-IV) were significantly different(P<0.05). A significant negative correlation (r=-0.473 P<0.01) was observed between the p16 and Ki-67 labeling indexes(LI). Conclusion Expression of p16 and Ki-67 antigen are of significance in evaluating the pathological grades and biological behavior of brain glioma.