长春瑞滨联合顺铂治疗晚期NSCLC 110例临床观察

Navelbine and cisplatin combined chemotherapy in the treatment of advanced non-small cell lung cancer

目的 观察长春瑞滨 (NVB) +顺铂 (PDD)联合化疗方案治疗晚期非小细胞肺癌的疗效及毒副反应。方法 自 1998年至 2 0 0 2年对 110例中晚期NSCLC进行NVB +PDD联合化疗 ,NVB 2 5mg /m2 ,第 1,8天用。PDD 6 0 80mg /m2 分三天用 ,2 1天为一个周期 ,至少应用两个周期。结果 全组总有效率为 4 7.3% ,其中初治有效率为 4 8.7% ,复治有效率为 4 3.8%。IIIa期有效率为 5 2 .2 % ,IIIb期有效率为 5 3.1% ,IV期有效率为 4 1.8%。腺癌有效率为 5 2 .3% ,鳞癌有效率为 4 6 .7%。 (P >0 .0 5 )。化疗副反应主要是白细胞降低及静脉炎。白细胞下降占 93.6 % ,主要是I,II ,III度 ,分别为 32 .7% ,38.2 % ,18.2 %。静脉炎发生率为 14 .5 %。结论 NVB +PDD方案治疗NSCLC疗效较好 ,毒副反应较轻 ,可以耐受。

ObjectiveTo evaluate the efficacy and toxicity of combination chemotherapy with navelbine (NVB) and cisplatin (PDD) in the treatment of advanced non-small cell lung cancer (NSCLC). MethodsFrom 1998 to 2002, 110 patients with NSCLC were treated with NVB plus PDD.NVB was given at a dose of 25 mg /m 2 on day 1 and 8,PDD 60-80 mg /m 2 within 3 days. 21 days was one circle,with at least two circles. Results The overall response rate (RR)was 47.3%, 48.7% for the first treatment cases and 43.8% for the multi- treatment cases. RR of stage III_ a ,III_ b and IV was 52.2%,53.1% and 41.8% respectively. RR of adenocarcinoma and squamous cell carcinoma was 52.3% and 46.7% respectively (P>0.05).The common toxicities were myelosuppression and phlebitis. Drop of WBC accounted for 93.6% and phlebitis for 14.5%. Conclusion Combination chemotherapy with NVB and PDD is an effective method to treat advanced NSCLC, and toxicities are low.