肺癌组织中HLA-DR抗原表达的临床意义

Clinical significance of HLA-DR antigen expression in lung carcinomas

目的 探讨HLA-DR抗原在肺癌中的表达及其临床意义。方法 采用免疫组化ABC法检测57例原发性肿癌组织中HLA-DR抗原表达情况,并分析了该抗原表达与癌临床病理的关系结果 57例肺癌组织中,腺癌、鳞癌和大细胞未分化癌的阳性表达率分别为72.0％、42.1％和28.6％,6例小细胞未分化癌(SCLC)和20例癌旁组织均未见阳性表达。腺癌的阳性率明显高于鳞癌和大组胞未分化癌(P<0.05)。随着肿瘤进展,HLA-DR表达逐渐降低,Ⅰ期和Ⅱ+Ⅲ期之间其阳性率差异有显著性(P<0.05),分化程度高的肺癌HLA-DR阳性表达率明显高于中、低分化程度的肺癌(P<0.01)。HLA-DR表达与肺癌有无淋巴结转移无明显相关性(P>0.05)。结论 HLA-DR异常表达可能是肺癌发生和发展过程中的标志物之一,对判断肺癌患者的生物学行为具有一定的意义。

Objective To investigate the expression of HLA-DR in lung carcinomas and its clinical significance . Methods Paraffin embedded tissues from 57 cases of primary lung carcinomas were studied for expression of HLA-DR by immunohistchemistry(ABC method) .The relationship between HLA-DR expression and clinical pathology of lung carcinomas was analyzed. Results Positive rate of HLA-DR expression in adenocarcinoma, squa-mous cell carcinoma and large cell un-differentiated carcinoma was 72.0%,42. 1% and 28.6 %, respectively. There was no expression of HLA-DR in 6 cases of SCLC and 20 cases of normal lung cells immediately adjacent to lung carcinomas. The positive rate of HLA-DR expression in adenocarcinoma was significantly higher than that in squamous cell carcinoma and larg cell un-differentiated carcinoma( P < 0.05) .The positive rate of HLA-DR expression gradually decreased with tumor progression. There was a distinct statistical difference in positive rate between stage Ⅰ and stageⅡ + stageⅢ ( P < 0.05) .HLA-DR expression in well differentiated carcinomas was significantly higher than that in moderately and poorly differentiated ones( P < 0.01). Primary lung carcinoma with lymph node metastasis did not show higher expression of HLA-DR than lung carcinoma without lymph node metasta-sis( P > 0.005). Conclusion Expression of HLA-DR might play a role in the genesis and development of lung carcinoma and can be used for judging its biological behavior.