CAP方案联合干扰素治疗晚期卵巢癌的临床疗效观察

Investigation on CAP scheme combined with interferon(IFN) in treatment of terminal stage of ovarian car-cinoma

目的 比较CAP方案与CAP+IFN-α 2a方案治疗晚期卵巢癌的临床疗效和毒副作用。方法 92例患者经术后病理证实为卵巢上皮癌,随机分为两组。A组44例,采用CAP方案;B组48例,采用CAP+IFN-α 2a方案。结果 B组有效率、3,4年生存率和中位生存期均优于A组,差异有显著性。B组发热反应较A组明显,其余毒副反应相似。结论 干扰素联合化疗远、近期疗效明显优于单纯化疗。CAP+IFN-α 2a是一种较好的联合化疗方案。

Objective To compare the curative effect, toxic and side effects of CAP scheme with CAP scheme combined with IFN on advanced ovarian carcinoma. Methods 92 cases of ovarian carcinoma conafirmed by pathological examination after operation were divided into 2 groups. CAP scheme was used in group A consisting of 44 cases and another 48 cases used CAP + IFN-α 2a, as group B. Results The data showed that the total effective rate,3-and 4-year survival rates and median survival time of groups B were higher than those group of A.The fever reaction of group B was stronger than group A, while other toxic and side effects were similar. Conclusion The efficacy of treatment of advanced ovarian carcinoma in group B was higher than that in group A with significant difference. Both methods had equivalent toxic and side effects which could be tolerated by patients. Group B is a better chemotherapeutic scheme for advanced ovarian carcinoma.