舒洛地特和洛沙坦对糖尿病肾病血栓调节蛋白和尿微蛋白排泄率的影响

目的观察舒洛地特和洛沙坦对糖尿病肾病血栓调节蛋白和尿微蛋白排泄率的影响。方法选择糖尿病肾病病人85例,随机分为对照组和治疗组,两组同时给予常规综合治疗。对照组只给予常规治疗,治疗组在对照组的用药基础上加用舒洛地特和洛沙坦常规剂量治疗,6周后测定两组病人空腹血糖(FBG)、血清果糖胺(Fs)、血栓调节蛋白(TM)与血β_2微球蛋白(β_2MG)的变化。结果治疗组血清果糖安、血栓调节蛋白明显低于对照(p<0.05),血β_2微球蛋白则极明显低于对照组(p<0.01)。结论舒洛地特和洛沙坦可以有效地改善糖尿病肾病的肾功能。

Objective To observe the changes of TM and serumβ2 MG in patients with diabetic nephropathy (DN) treated by Sulodexide and Lossatan potassium. Methods 85 patients with DN were divided into treatment and control groups at random. Two groups were treated routinely with general treatment on DM and the treatment groups was added routine dose of Sulodexide and Lossatan potassium. After 6 weeks, FBG, Fs, TM and serum β2 MC were determined. Results Fs and TM in treatment group were lower markedly than control group, serum β2 MG in treatment group were lower very markedly than control group. Conclusion Sulodexide and Lossatan potassium can improve effectively renal function of DN.