3种苯基-5-烷基-2-氨基-1、3、4-噻二唑硫脲化合物的合成研究

Study on Synthesis of Three Phenyl-5-alkyl-amino- 1、3、4-thiodiazole-thiourea compounds

研究了以 5 -烷基 - 2 -氨基 - 1、3、4 -噻二唑为中间体和苯异硫氰酸酯 (PTTC)合成苯基 - 5 -烷基 - 2 -氨基- 1、3、4 -噻二唑硫脲 3种化合物。并确定了最优化合成条件 :反应物的物质的量比为 1∶1.8,四丁基溴化铵 (0 .8g)为催化剂 ,10mL乙腈为溶剂 ,加热回流 4h ,产率可达 74 .5 6 %、6 4 .80 %、5 3.5 4 %。实验方法简单 ,时间短 ,产率高 ,具有很高的理论和实际应用价值。

In this paper, the synthesis of three phenyl-5-alkyl-2-amino-1,3,4-thiodizole-thiourea is studied.The optimum reaction conditions are the ratio of phenyl-5-alkyl-2-amino-1、3、4-thiodizole with PTTC is 1: 1.8 ,0.8 g tetrabutyl ammonium bromide being catalyst,10 ml methyl cyanide as the solvent and the reflux time 4.0 h,the each yiesd can reach 74.56%,64.80%,53.54%.This method has high theoretical and practical valne with simply,reduced time and high ratio.