益肾健脑颗粒剂对脑萎缩肾阴虚血瘀证主症及血流变的影响

Effects of granules for nourishing kidney and strengthening brain on main symptoms of kidney-yin deficiency and blood stasis syndrome and hemorrheological characteristics of brain atrophy

目的 :观察益肾健脑颗粒剂对脑萎缩患者肾阴虚血瘀证主症及血流变的影响。方法 :脑萎缩肾阴虚血瘀证患者90例 ,随机分为 2组。治疗组 60例用滋肾健脑中药所组成的益肾健脑颗粒剂治疗 ,对照组 3 0例用吡拉西坦片治疗 ,2组均治疗 8周。结果 :治疗组脑萎缩的总有效率为 86.6% ,对照组为 73 .3 % ,两组比较有显著性差异 (P <0 .0 5)。治疗组主症记分值的改善明显优于对照组 (P <0 .0 1) ,简易智能状态检查明显改善 ,与对照组比较 ,P <0 .0 1;长谷川痴呆量表评分和日常生活能力评分提高 ,但与对照组比较无显著差异 ;血小板聚集率明显改善 ,与对照组比较 ,P <0 .0 5;全血黏度亦有改善 ,但与对照组比较无显著差异。结论 :益肾健脑颗粒剂对脑萎缩肾阴虚血瘀证有较好的临床疗效 。

Objective:To explore the influence of granu le s for nourishing kidney and strengthening brain (GNKSB) on main symptoms of kidn ey-yin deficiency and blood stasis syndrome and the hemorrheological characteri stics of brain atrophy patients. Methods: Ninety patients of brain a trophy with kidney-yin deficiency and blood stasis syndrome were randomly divid ed into two groups. Sixty cases in treatment group were treated with GNKSB, and the 30 cases in control group were treated with piracetam for 8 weeks. Results: The effective rate of treatment group was 73.3%, with significa nt difference as compared with 46.6% of the control group ( P<0.01 ). The scores of symptom-assessment of the two groups were also significantly diff erent (P< 0.01 ). The mini-mental state examination of treatment group wa s obviously improved, and was significantly different as compared with the contr ol group (P<0.01). The scores of Hasegawa’s dementia scale and activities o f daily living were increased, but without significant difference as compared wi th the control group. The platelet aggregation rate was improved, with significa nt difference as compared with the control group (P<0.05). The whole blood v iscosity was also improved obviously, but without significant difference as comp ared with the control group. Conclusion: GNKSB is effective for kidn ey-yin deficiency and blood stasis syndrome of brain atrophy patients and can i mprove their mental state and the hemorrheological indexes.