三生化痰汤在非小细胞肺癌化疗中的应用

Treatment of non-small-cell lung cancer with chemotherapy and Sansheng Huatan Decoction

目的 :验证中药“三生化痰汤”在治疗中、晚期原发性非小细胞肺癌中对化疗药物的增效减毒作用。方法 :将细胞学或组织病理学证实的中、晚期非小细胞肺癌患者 160例随机分为 2组。治疗组采用中西药结合治疗 ,即中药“三生化痰汤”加全身化疗 ;对照组为单纯全身化疗。分析两组在客观疗效指标、生活质量、NK细胞活性、肝肾功能、血常规指标方面的差别。结果 :治疗组客观疗效指标有效率 (56.7% )高于对照组 (48.2 % ) ,但无统计学差异 (P >0 .0 5) ;治疗组在生活质量的改善及提高NK细胞活性、减轻血液学毒性方面明显优于对照组 (P <0 .0 1)。结论 :三生化痰汤对非小细胞肺癌的化疗有一定的增效作用 ,对减轻化疗药物的毒副反应。

Objective:To observe the clinical effect of C hinese medicine Sansheng Huatan Decoction combined with chemotherapy in treating advanced primary non-small-cell lung cancer and to evaluated the effect of Sa nsheng Huatan Decoction increasing clinical effect and decreasing toxicity in ch emotherapy for non-small-cell lung cancer. Methods: One hundred an d sixty patients of advanced primary non-small-cell lung cancer proved by path ological examination were randomized into two groups. The treatment group was tr eated with Sansheng Huatan Decoction and chemotherapy, and the control group was treated only with chemotherapy. The clinic effect, life quality, natural killer (NK) activities, liver and kidney functions, and blood routine test of the 2 gr oups were evaluated. Results:The clinical effective rates of the tr eatment and control groups were 56.7% and 48.2% respectively, and there was no s tatistic significance (P>0.10). The life quality, NK activities and blood ro utine test of the treatment group were better than those of the control group. Conclusion: Sansheng Huatan Decoction combined with chemotherapy is a better treatment for non-small-cell lung cancer as compared with chemotherapy .