宫环止血片止血及镇痛作用的实验研究

Hemostatic and analgesic effect of Gonghuan Zhixue Tablet on mice

目的 :探讨宫环止血片对小鼠的止血、镇痛作用 ,为开发治疗铜宫内节育器所致子宫异常出血的新药提供实验依据。方法 :以氨基己酸、三七粉作对照 ,采用毛细玻管及小鼠断尾法观察宫环止血片对小鼠凝血、出血时间的影响 ;以阿司匹林作对照 ,采用热板法及扭体法观察宫环止血片对小鼠的镇痛作用。结果 :宫环止血片随剂量的增加而明显缩短小鼠凝血时间 ,各治疗组和蒸馏水组比较都有显著性差异 ;宫环止血片与蒸馏水组比较 ,各剂量组都能明显缩短出血时间 ;宫环止血片各剂量组均能延长小鼠热板痛反应时间及减少小鼠扭体次数。结论 :药理实验证明宫环止血片具有显著的止血。

Objective:To explore the hemostatic and analgesic effect of Gonghuan Zhixue Tablet (GHZXT) on mice and to produce experimental evidence for exploiting new drug for endome trorrhagia caused by Cu-intrauterine contraceptive device (Cu-IUD). Meth ods: Compared with 6-aminocaproic acid and notoginseng, the effects of GH ZXT on clotting and bleeding time of mice with capillary method and severed tail were investigated; and compared with aspirin, the analgesic effects of GHZXT on mice were investigated with hot plate and torsive body method. Results: The clotting time of mice was remarkably shortened with a rising of the dos age of GHZXT and the difference between each therapeutic group and distilled wat er group was remarkable. As compared with distilled water group, the bleeding ti me of each dosage group of GHZXT was obviously shortened; and each dosage of GHZ XT could prolong the time of pain reaction to hot plate and decrease the degree of torsive body of the mice. Conclusion: Pharmacological experiment has proved that GHZXT has evident hemostatic and analgesic function.