葛根汤抗炎、止痛有效部位的研究

On the Active Parts of “ Gegen Decoction” in Fighting Inflammation and Pain

为研究葛根汤抗炎、止痛的有效部位。根据该方中各中药有效成分理化性质的不同 ,利用不同方法对葛根汤水煎液进行提取分离 ;将提取分离所得组分两两组合 ,用于抗炎、止痛实验 ,以筛选有效部位 ;通过HPLC等对筛选的有效部位进行定性研究。结果 :不加任何提取的水煎剂的抗炎作用略好于其他组 ;而在止痛方面 ,由乙醚提取液、正丁醇提取液和经上述提取后余下的水层三者混合液 ,效果较好 ,但无组间差异。认为乙醚提取部分合正丁醇提取部分 ,为该方抗炎。

To determine the active parts of “ Gegen Decoction” in fighting inflammation and pain, the ingredients of the Decoction were extracted with different methods and then used to relieve inflammation and pain. Results showed that the ingredients extracted with all methods were quite effective for inflammation; however, the ingredients extracted with ether, n butyl alcohol and in the water left were effective for pain relief.