新生儿窒息后血中胃肠激素水平的测定和临床意义

Measurement of blood gastrointestinal hormones and their clinical value in asphyxia newborns

目的 :探讨新生儿窒息后血中胃泌素、胃动素的变化及临床意义。方法 :采用放射免疫法测定 38例窒息新生儿 (其中轻度窒息 2 0例、重度窒息 18例 )和 30例无消化系统疾病的新生儿上述2种胃肠激素水平 ,并进行相关分析。结果 :①轻度窒息组血中胃泌素、胃动素与对照组比较无显著性意义 (P >0 .0 5 ) ,②重度窒息组血中胃泌素、胃动素水平则明显低于对照组 ,有显著性意义 (P <0 .0 1)。结论 :①轻度窒息新生儿血中胃泌素、胃动素的水平基本同正常新生儿 ,提示可酌情早期喂养。②重度窒息新生儿血中胃泌素、胃动素的水平明显降低 ,提示早期喂养将会导致喂养不耐受。

Objective: To study the changes of serum gastrins and motilin in asphyxia newborns and explore their clinical value. Methods: Radiation immunoassays were used to detect the serum gastrins and plasma motilin in 38 asphyxia newborns (20 new born with low-grade asphyxia, 18 new born with severe asphyxia) and 30 new born without digestive system disease. Then analyzed their correlations. Results: ①The differences of serum gastrins and plasma motilin between low-grade asphyxia group and contrast group had not significant respectively( P>0.05 ).②There was significant difference of serum gastrins and plasma motilin between severe asphyxia group and contrast group(P<0.01). Conclusions: ① The level of serum gastrins and plasma motilin in low-grade asphyxia and normal new born was alike,which suggested that forepart feed could be taken into consideration. ② The level of serum gastrins and plasma motilin in severe asphyxia reduce obviously. It suggested that forepart feed would lead to unbearable feed.