硫酸镁和酚妥拉明联合治疗支气管哮喘31例疗效观察

Clinical study on the efficacy of magnesium sulfate and phentolamine in treatment of 31 asthma patients

目的 :探讨硫酸镁和酚妥拉明联合治疗哮喘的疗效。方法 :将 4 7例重度哮喘患者分为 2组。对照组 16例用单纯常规治疗。治疗组 31例在常规治疗基础上 ,加用 2 5 %硫酸镁 10ml,酚妥拉明10mg加入 5 %葡萄糖氯化钠溶液 2 5 0ml静脉滴注 ,滴速为每分钟 15滴 ,每天 1次 ,根据病情连用 3～6d。结果 :对照组用药 4 8h内有效者 5例 ,4 8h以上有效者 9例 ,无效 2例 ,有效率为 87.5 %。治疗组用药 4 8h内有效者 2 8例 ,4 8h以上有效者 3例 ,有效率为 10 0 %。治疗组有效率显著高于对照组 (P <0 .0 5 )。结论 :在常规疗法的基础上 ,加用硫酸镁和酚妥拉明 ,可提高治疗支气管哮喘的疗效。

Objective: To discuss the effects of the treatment of asthma by using both Magnesium Sulfate and Phentolamine. Methods: Divided 47 serious asthma patients into 2 groups-contrasted group and clinic group. 16 patients belonging to the contrasted group received only conventional treatment. 31 patients belonging to the clinic group received not only conventional treatment but also the treatment by using 10ml solution of 25% Magnesium sulfate and 10mg Phentolamine mixed with 250ml 5%GNS by means of intravenous dripping. The rate is 15 drops one minute, quaque die. Kept giving such treatment for 3 to 6 days in succession, depending on the patient’s condition. Results: In the contrasted group 5 cases showed effects within 48 hours of treating. In longer than 48 hours of treating, 9 cases showed effects. 2 cases showed no effects. The curative effect rate is 87.5%. In the clinic group, 28 cases showed effects within 48 hours of treating and 3 cases did in longer than 48 hours of treating. The curative effect rate is 100%. The curative effect rate of the clinic group is obviously higher than that of the contrasted group (P<0.05). Conclusion: In addition to conventional treatment, using Magnesium sulfate and Phentolamine can raise the curative effect rate of treating asthma.