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线粒体膜间蛋白在凋亡中的作用 被引量：1

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摘要 线粒体在衰老中起重要作用不仅由于它是反应氧簇的主要来源和目标,而且在于它能调节应激反应和细胞凋亡。本文就细胞凋亡中起重要作用的线粒体膜间蛋白如细胞色素c、Smac/DIABLO、凋亡诱导因子、核酸内切酶G、Omi/TtrA2等进行了综述。
作者 蒋建明 李电东
机构地区 中国协和医科大学中国医学科学院医药生物技术所
出处 《国外医学（老年医学分册）》 2004年第2期59-63,共5页 Foreign Medical Sciences(Geriatrics)
基金 国家自然科学基金项目(项目号:30070827) 国家重点基础研究发展计划(NO.G2000057010)
关键词 线粒体 膜间蛋白 细胞凋亡 细胞色素C 应激反应
分类号 R341 [医药卫生—基础医学]
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参考文献19

  • 1Hengarther MO. The biochemistry of apoptosis, Nature,2000; 407 (6805): 770-776.
  • 2Sastre J, ederico V. The role of mitochondrial oxidative stresss in aging. Free Radical Bilogy & Medicine, 2003 ; 35 ( 1 ) :1-8.
  • 3Adams JM, CoW S. Apoptosomes: engines for caspase activation. Cart Opin Cell Bid, 2002; 14 (6) : 715-720.
  • 4Joza N, Susin SA, Daugas E et at. Essential role of the mltochondrial apoptosis-inducing factor in programmed cell death. Nature, 200l; 410 (6828): 549-554.
  • 5Marsden VS, Connor LO, Reilly LA et al. Apoptosis initiated by Bcl - 2 - regulated caspase activation independently of the cytochrome c/Apaf- 1/caspase -9 apoptosome. Nature, 2002; 419 (6909): 634-637.
  • 6Verhagen AM, Ekert PG, Pakusch Met al, Identification of DIABLO, a mammalian protein that promotes apoptosis by binding to and antagonizing IAP proteins. Cell, 2000; 102 (1): 43-53.
  • 7Roberts DL, Merrison W, MacFarlane M et al. The inhibitor of apoptods protein -binding domain of Smac is not essential for its proapoptotic activity. J Cell Biol, 2001 ;153 (1) : 221-228.
  • 8Cande C, Cecconi F, Dessen Pet al. A4x3ptosisinducing factor (AIF) : key to the conserved easpase- independent pathwaysof cell death. J Cell Sci, 2002; 115 (24): 4727-4734.
  • 9Wang X, Yang C, Chai Jet al. Mechanisms of ,AIF mediated apoptotic DNA degradation in Caenorhabditis elegans, Science, 2002; 298 (5598): 1587-1592.
  • 10Joza N, Susin SA, Daugas E et al. Essential role of the mitochondrlal apoptosls- inducing factor in prcNrammed cell death. Nature, 2001; 410 (6828): 549-554.

同被引文献34

  • 1Everett H, McFadden G. Viruses and apoptosis: meddling with mitochondria[J]. Virology, 2001, 288(1): 1-7.
  • 2胡野, 凌志强, 单小云. 细胞凋亡的分子医学[M]. 北京: 军事科学出版社, 2003.87.
  • 3Kharbanda S, Pandey P, Schofield L, et al. Role for Bcl-xL as an inhibitor of cytosolic cytochrome C accumulation in DNA damage-induced apoptosis[J]. Proc Natl Acad Sci U S A, 1997, 94(13): 6939-6942.
  • 4Kleibl Z, Raisova M, Novotny J, et al. Apoptosis and its importance in the development and therapy of tumors[J]. SB Lek, 2002, 103(1): 1-13.
  • 5Fulda S, Wick W, Weller M, et al. Smac agonists sensitize for Apo2L/TRAIL- or anticancer drug-induced apoptosis and induce regression of malignant glioma in vivo[J]. Nat Med, 2002, 8(8): 808-815.
  • 6Acehan D, Jiang X, Morgan DG, et al. Three-dimensional structure of the apoptosome: implications for assembly, procaspase-9 binding, and activation[J]. Mol Cell, 2002, 9(2): 423-432.
  • 7Adams JM, Cory S. Apoptosomes: engines for caspase activation[J]. Curr Opin Cell Biol, 2002, 14(6): 715-720.
  • 8Susin SA, Lorenzo HK, Zamzami N, et al. Molecular characterization of mitochondrial apoptosis-inducing factor[J]. Nature, 1999, 397(6718): 441-446.
  • 9Susin SA, Daugas E, Ravagnan L, et al. Two distinct pathways leading to nuclear apoptosis[J]. J Exp Med, 2000, 192(4): 571-80.
  • 10Guo Y, Srinivasula SM, Druilhe A, et al. Caspase-2 induces apoptosis by releasing proapoptotic proteins from mitochondria[J]. J Biol Chem, 2002, 277(16): 13430-13437.

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国外医学（老年医学分册）
2004年 第2期

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