喉神经内分泌肿瘤临床特征

The clinical feature of laryngeal neuroendocrine neoplasms

目的 :探讨喉神经内分泌肿瘤的临床表现、诊断及治疗。方法 :回顾分析我科收治的 3例喉神经内分泌肿瘤 ,其中非典型类癌 2例 ,行根治性手术切除及颈廓清术 ;嗜铬细胞瘤 1例 ,行肿瘤局部切除术。结果 :非典型类癌 2例 ,术后随访 1年 ,情况稳定。嗜铬细胞瘤 1例 ,术后随访11年 ,预后良好。结论 :喉神经内分泌肿瘤是一组形态各异的病变 ,正确诊断有赖于临床特点、光镜、免疫组织化学检查 ,部分患者需行超微结构检查。不同类型的肿瘤应行不同的治疗方法。

Objective:To study the clinical manifestation, diagnosis and treatment of laryngeal neuroendocrine neoplasms. Method: Three cases of laryngeal neuroendocrine neoplasms were analyzed, of which two cases were diagnosed as atypical carcinoids with radical surgery and neck dissection, another case was diagnosed as asparaganglioma through local neoplastic removal. Result: Two patients of atypical carcinoids are in a good condition after following up one year and another patient of asparaganglioma is with good prognosis after following up eleven years.Conclusion: Laryngeal neuroendocrine neoplasms are composed of a morphologically heterogeneous group of lesions. Accurate diagnosis is primarily based on clinical characteristic, microscopic and immunohistochemical examination. In some instances, it may be supported by ultrastructural studies. Difference treatment should be provided to different classified tumor.