CD45ROCD20及总IgE在声带息肉组织中表达的研究

Roles of CD45RO,CD20 and local IgE in the pathogenesis of vocal fold polyps

目的 :从免疫病理学角度探讨细胞免疫、体液免疫和局部变态反应在声带息肉发病中的作用。方法 :对 30例声带息肉组织 (息肉组 )和 10例正常声带组织 (对照组 )采用免疫组织化学方法观察两组CD4 5RO、CD2 0及IgE的表达情况并检测其阳性细胞数。 结果 :息肉组CD4 5RO、CD2 0和IgE阳性细胞数显著高于对照组 (P <0 .0 1) ;声带息肉组织中CD4 5RO、CD2 0和IgE的表达之间无相关性 ;男、女患者间的表达差异亦无统计学意义 (P >0 .0 5 )。 结论 :由T淋巴细胞介导的细胞免疫和B淋巴细胞介导的体液免疫在声带息肉中免疫应答活跃 ;声带黏膜局部变态反应参与了声带息肉的发病 ;在声带息肉的发病机制中免疫病理改变起着重要的作用。

Objective:To investigate the roles of CD45RO,CD20 and local IgE in the pathogenesis of vocal fold polyps.Method:Thirty cases of vocal fold polyps and ten cases of normal vocal folds were used in present study by immunohistochemical method to detect the CD45RO,CD20 and IgE cells.A mean numbers of postive cells per high power field(×400)were counted.All data were analyzed with t-test and correl-test by SPSS10.0 software.Result:The number of CD45RO + cells ?CD20 + cells and local IgE cells in vocal fold polyps was significantly more than in normal vocal folds (P< 0.01 ). The expression of CD45RO + cells ?CD20 + cells and local IgE + cells in vocal fold polyps was no connection relations. The expression of CD45RO + cells ? CD20 + cells and local IgE cells between male and female vocal fold polyps was no significant(P> 0.05 ). Conclusion:There were active cellular immunity and humoral immunity in vocal fold polyps.Local allergy may play a role in the pathogenesis of vocal fold polyps.