黏着斑激酶在喉癌中的表达及临床意义

Expression of focal adhesion kinase in laryngeal carcinoma

目的 :探讨黏着斑激酶 (FAK)在喉癌及癌旁组织中的表达及其与喉癌的临床分期、生存率、转移等生物学行为的关系。方法 :应用免疫组织化学法检测 10 0例喉癌及 6 0例癌旁组织石蜡标本中FAK的表达水平。结果 :FAK在喉癌中的表达明显高于癌旁组织 (P <0 .0 5 ) ;Ⅲ、Ⅳ期表达较Ⅰ、Ⅱ期高 (P <0 .0 5 ) ;FAK表达较强阳性和强阳性者 3、5年生存率分别为 76 .9%(5 0 /6 5 )和 6 1.5 %(4 0 / 6 5 ) ,而阴性和弱阳性者 3、5年生存率分别为 97.1%(34/ 35 )和 88.6 %(31/ 35 ) ,其差异均有统计学意义 (P <0 .0 1)。结论 :FAK的表达可作为了解喉癌肿瘤细胞生物学行为、转移及预后判断的一种较有价值的病理指标。

Objective:To evaluate the pattern of FAK expression in laryngeal squamosa cell carcinoma and noncarcinoma tissue.Method:Expression of FAK was examined in 100 specimens with laryngeal squamosa cell carcinoma and 60 specimens with noncarcinoma, in which 8 cases were in stageⅠ, 23 cases in stage Ⅱ, 38 cases in stage Ⅲ and 31 cases in stage Ⅳ.Result:The staining of FAK was stronger in laryngeal squamous cell carcinomas than in the cell of noncarcinoma areas. The cancers with lymphnode metastasis had more FAK protein than the cancers with out lymph node metastasis .Survival rate at 3 and 5 years was 76.9 %(50/65)and 61.5 %(40/65)respectively for positive staining group of FAK, compared to 97.1 %(34/35)and 88.6 %(31/35) respectively for negative staining group.Conclusion:The results in the report show that the level of FAK expression might be a valuable marker for carcinogeneandsis and the progression of carcinoma.