病毒唑的合成新工艺

A New Sythesis of Ribavirin

目的:采用合成新工艺提高病毒唑的收率。方法:用肌苷为原料,经乙酰化后在双磷酸酯的作用下与1,2,4-三氮唑-3-羧酸甲酯缩合,再经氨解制得产品。结果:以肌苷计,总收率为48%。结论:该合成路线简单实用,易在生产中推广。

Objective:Using the new sythesis of Ribavirin to improve the yield.Method:Ino- sine was acetylated to tetracetylribofuranose,which was condensed with Me 1,2,4-trazole-3-car- boxylate b the aiding of bisphosphate.Then treated with NH_3 to give Ribavirin.Result:The over- all yield was 48% on the basis of inosine.Conclusion:This new synthesis route is simple and use- ful,can be easily realized in the wide production.