辐射损伤与细胞周期

Radiation injury and cell cycle

辐射后的细胞可能发生恶性转化,可能死亡,另有一些细胞对辐射却产生适应性或抗性,最终长期存活下来。近年来研究发现,此差异与辐射对细胞周期的影响密切相关。辐射可阻断细胞周期活动及延长细胞周期,其中G1期、S期和G2/M期等细胞周期检查点(checkpoint)起决定作用,它们分别通过不同的信号途径对辐射所致的损伤进行调控,产生不同的辐射生物学效应。对该领域的深入研究不仅为进一步阐释辐射致癌提供一定的理论依据,而且为临床放疗增敏剂的研制提供新的思路。

Some may be malignant transformation,some may die immediately,and the other may be alive which produce radioadaptive responses and radioresistance.Recently,it has been reported that there is close relationship between cell cycle alterations and different injury effects caused by radiation.Cell cycle may be arrested and delayed by irradiation in which G 1 -phase,S-phase and G 2 /M-phase checkpoints may play a major role.Therefore different signal transduction pathways and moleculars are involved in the checkpoints responses.Furthermore,studies on the cell cycle checkpoints responses to radiation are quite important in radiation biology,because it could not only provide the theorical basis for the elucidation of cancer caused by radiation,but also gain further insight into investigation and developing radiosensitive drugs for clinical radiotherapy.`