星形胶质细胞的电离辐射损伤及修复作用

Injury and repair of astrocyte after ionizing radiation

星形胶质细胞(astrocyte,Ast)是中枢神经系统内最多的胶质细胞。体内外实验结果表明,电离辐射作用于神经系统后,可引起神经元、胶质细胞和血管内皮细胞等多种细胞的形态和功能变化。照射后早期Ast即可发生反应,与脑组织损伤后的病理过程及损伤后修复有着密切的联系。研究Ast在辐射损伤中的作用对于临床放射性脑损伤的治疗有着重要的意义。

Astrocyte is the most glial cell in the central nervous system.In the present experi-ment,radiation injury to the central nervous system(CNS)triggers a large network of cellular changes including neuron,glialcell and endothelial cell in morphology and metabolism and function.Astrocyte changes rapidly after ionizing radiation.There is a ralationship between astrocyte and the pathologic process and function recover of damaged brain tissue following CNS injury.This suggests that astrocyte plays an important role in cure of clinical radiation injury.