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加替沙星的HPLC测定 被引量:2

Determination of Gatifloxacin by HPLC
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摘要 建立了加替沙星的HPLC测定法。采用Nova-pak C18色谱柱,三乙胺磷酸溶液-乙腈(87∶13)为流动相,柱温40℃,检测波长325nm。并对加替沙星及其制剂的稳定性进行了考察。 A HPLC method for determination of gatifloxacin and its related substances was established. A C18column was used with the mobile phase of triethylamine phosphoric acid solution-acetonitrile(87∶13), at the detectionwavelength of 325nm. The column temperature was 40℃. The stability of gatifloxacin and its dosage forms was examined.
出处 《中国医药工业杂志》 CAS CSCD 北大核心 2004年第3期172-173,共2页 Chinese Journal of Pharmaceuticals
关键词 加替沙星 稳定性 高效液相色谱 测定 gatifloxacin stability HPLC determination
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参考文献2

  • 1[1]Ren Y,Ye K,Zhu CQ,et al.Synthesis and antibacterial activity of novel 6-fluoroquinolone analogs[J].Yaoxue Xuebao,1995,30(5):357-366.
  • 2[2]Sanchez JP,Gogliotti RD,Rocco D,et al.The synthesis,structure-activity and structure-side effect relationships of a series of 8-alkoxy- and 5-amino-8-alkoxyquinolone antibacterial agents[J].J Med Chem,1995,38(22):4478-4487.

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