摘要
电致孔可显著提高药物的经皮吸收,有望用于多肽和蛋白质类生物大分子药物的透皮给药。本文对电致孔法的透皮促渗机制、影响因素以及安全性进行了讨论,并介绍了有关实验装置及其在透皮给药中的应用。
During electroporation, membrane permeability is temporarily increased by orders of magnitude, therebythe transmembrane transport of compounds as well as macromolecules such as peptides and proteins is enhanced. Themechanisms,experimental devices and the influence factors of electroporation are reviewed. The application and the safetyof the electroporation in transdermal drug delivery are also introduced.
出处
《中国医药工业杂志》
CAS
CSCD
北大核心
2004年第3期174-179,共6页
Chinese Journal of Pharmaceuticals
关键词
透皮给药
电致孔
综述
transdermal drug delivery
electroporation
review
