减肥保健品中芬氟拉明等8种合成食欲抑制剂的分析测定

Analysis of 8 Synthetic Anorexics in Adulterated Weight-reducing Tonic

建立了用气相色谱同时测定减肥保健品中芬氟拉明、苯丁胺 ,苄非他明、氯苯丁胺、氯苄苯丙胺、苯双甲吗啉、苯甲吗啉及安非泼拉酮等 8种合成食欲抑制剂的方法 ,检出限 <10 0 μg /L。分析结果用GC/MSD进一步确证 ,准确、可靠。

Eight synthetic anorexics, fenfluramine(FEN), phentermine(PHE), benzphentermine(BPT), chlorphentermine(CPT), clobenzorex(CBZ), phendimetrazine(PDM), phenmetrazine(PHM), and amfepramone(AFP), which can be found as adulteratants in traditional Chinese tonic for losing body weight, were assayed simultaneously by gas chromatography/nitrogen phosphorous detector (GC/NPD) and gas chromatography/mass selective detector (GC/MSD). Sample preparation and recoveries of the synthetic anorexics from tonic of different matrixes were studied. Detection limits were lower than 100 μg /L for all the 8 synthetic anorexics in different matrixes. The method was applied to 2 real samples purchased from Chinese market, and fenfluramine was found in both of the samples.