摘要
提出一个简单有效的蛋白质设计方法 ,这一方法完全基于物理学原理 .与同类工作相比 ,该方法在很大程度上可节省对序列空间进行的搜索 ,是对同类工作的简化与发展 .对三个平面格子模型进行的检验表明该方法是成功的 .
A new simple and effective approach completely based on the physical theory is proposed for protein design. Compared with the similar works, the algorithm saves a vast deal of trouble in exploring sequence space. The method is an improvement over previous works. The design procedure was tested on three lattice models in two dimensions and the successful results have been obtained. The method can be readily implemented for three dimensional off lattice models of real proteins.
出处
《生物化学与生物物理进展》
SCIE
CAS
CSCD
北大核心
2004年第2期172-176,共5页
Progress In Biochemistry and Biophysics
基金
国家自然科学基金 ( 10 1740 0 5
3 0 170 2 3 0 )
北京市自然科学基金 ( 5 0 3 2 0 0 2 )资助项目
