支气管肺泡灌洗介入抗生素凝胶治疗支气管扩张合并感染观察

Broncho-alveolar lavage (BAL) antibiotic intervention therapy for bronchiectasis combined pulmonary infection

目的 探讨支气管肺泡灌洗介入抗生素凝胶治疗支气管扩张合并肺感染疗效。方法 将 6 0里碘油造影或CT证实支气管扩张病人合并感染者 ,随机分为两组。一组为介入抗生素凝胶组 (凝胶组 ) :一组为注入水溶性抗生素组 (水剂组 )。二组均先行支气管肺泡灌洗及临床全身用药治疗。结果 凝胶组从治疗次数、药物在体内的存留时间及对病人咳嗽反应优于水剂组 (P <0 .0 1)。治疗过程安全、稳定、症状迅速消失 ,一般每周 1次。结论 支气管肺泡灌洗后介入抗生素凝胶治疗支气管扩张合并感染 ,具有提高疗效 ,抗生素凝胶在气道和脓腔内存留时间长起到缓释放作用 ,对气道反应性小 ,安全可靠的优点。

Objective: To evaluate the role of antibiotic interventional therapy by BAL for bronchiectasis combined pulmonary infection.Methods: Sixty patients confirmed by broncho-iodin-graphy and chest CT were separated into two groups randomly. Antibiotic gel and water-solubility antibiotic were injected respectively. All the patients received BAL and systematic therapy.Results: The therapy degree,keeping time of the medication and the reaction of cough were excel in the gel injection group than the other group. ( P <0.01) The procedure was safe and stable. The symptom of the patients was dissolved rapidly by the therapy once two weeks.Cnclusions: The therapy is effective and the keeping time of the gel is long. The stimulation to the airway is less. The procedure is safe.